Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1995-8-17
|
pubmed:abstractText |
The effects of adenosine on the L-type Ca2+ current (Ica) were studied in human atrial myocytes using the whole-cell voltage clamp technique. Ica was recorded under physiological calcium concentrations (1.8 mmol/l) at 37 degrees C. Under these conditions the current density of basal Ica averaged 4.0 pA/pF. Isoprenaline (1 mumol/l) increased basal Ica to 249.7%. Adenosine (100 mumol/l) in the presence of isoprenaline (1 mumol/l) decreased Ica from the level obtained with isoprenaline to 87.5% of basal Ica. Adenosine (0.1 to 100 mumol/l) also reduced basal Ica, maximally to 64.5% of control. Activation and inactivation parameters of basal Ica were not significantly different between adenosine (100 mumol/l) and control recordings. Our results show that adenosine affects both basal and isoprenaline stimulated Ica in human atrial myocytes. Although a considerable decrease of basal Ica was seen, we conclude that the action of adenosine on L-type Ca2+ current in human atrial myocytes is mainly antiadrenergic. Both effects may contribute to the antiarrhythmic properties of adenosine.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
0028-1298
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
351
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
293-7
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:7609783-Acetylcholine,
pubmed-meshheading:7609783-Adenosine,
pubmed-meshheading:7609783-Calcium Channel Blockers,
pubmed-meshheading:7609783-Cells, Cultured,
pubmed-meshheading:7609783-Heart Atria,
pubmed-meshheading:7609783-Humans,
pubmed-meshheading:7609783-Isoproterenol,
pubmed-meshheading:7609783-Membrane Potentials,
pubmed-meshheading:7609783-Myocardium,
pubmed-meshheading:7609783-Patch-Clamp Techniques
|
pubmed:year |
1995
|
pubmed:articleTitle |
Adenosine inhibits the L-type calcium current in human atrial myocytes.
|
pubmed:affiliation |
Institut für Medizinische Physik und Biophysik, Universität Graz, Austria.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|