Linked Life Data

760907

Source:http://linkedlifedata.com/resource/pubmed/id/760907

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1979-4-26
pubmed:abstractText
1. Potential changes between the pial and cut surfaces of slices of guinea-pig olfactory cortex in vitro produced by gamma-aminobutyric acid (GABA) were recorded with extracellular electrodes. 2. GABA, superfused over the pial surface (0.1 to 10 mM), produced a pial-negative potential deflection, accompanied by inhibition of the postsynaptic response to lateral olfactory tract (LOT) stimulation. 3. This effect was replicated by the following compounds (potency relative to GABA = 1, in brackets): 3-aminopropanesulphonic acid (5.3), epsilon-aminovaleric acid (0.07), beta-alanine (0.07), beta-amino-nibutyric acid 0.05), epsilon-aminocaproic acid, alpha-amino-isobutyric acid, L-leucine (less than 0.02). 4. L-Glutamate (1 to 10 mM) produced a very large surface negative shift, with relatively less synaptic inhibition. Glycine (1 to 10 mM) produced less surface negatively, accompanied by synaptic inhibition. 5. Responses to GABA were antagonized more effectively than those to glycine by bicuculline (3 to 30 micrometer) and picrotoxin (1 to 30 micrometer). Strychnine (1 to 10 micrometer) incompletely inhibited responses to glycine. 6. It is concluded that, while the locus within the slice of these effects is uncertain, the preparation may be useful for testing the interaction of drugs with cerebral GABA receptors.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/760907-1065522, http://linkedlifedata.com/resource/pubmed/commentcorrection/760907-1177140, http://linkedlifedata.com/resource/pubmed/commentcorrection/760907-1177867, http://linkedlifedata.com/resource/pubmed/commentcorrection/760907-212161, http://linkedlifedata.com/resource/pubmed/commentcorrection/760907-216454, http://linkedlifedata.com/resource/pubmed/commentcorrection/760907-4154116, http://linkedlifedata.com/resource/pubmed/commentcorrection/760907-4505419, http://linkedlifedata.com/resource/pubmed/commentcorrection/760907-4698282, http://linkedlifedata.com/resource/pubmed/commentcorrection/760907-4844456, http://linkedlifedata.com/resource/pubmed/commentcorrection/760907-5639925, http://linkedlifedata.com/resource/pubmed/commentcorrection/760907-5666180, http://linkedlifedata.com/resource/pubmed/commentcorrection/760907-667493
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0007-1188
pubmed:author
pubmed:issnType
Print
pubmed:volume
65
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
347-53
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1979
pubmed:articleTitle
Responses of the guinea-pig isolated olfactory cortex slice to gamma-aminobutyric acid recorded with extracellular electrodes.
pubmed:publicationType
Journal Article, In Vitro