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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
1995-8-11
|
| pubmed:abstractText |
To address the relationship of insulin-like growth factor-I (IGF-I) to diabetes control, we determined IGF-I levels in 137 subjects age 17 yr and younger with recently diagnosed insulin-dependent diabetes mellitus in a population-based cohort study between 3 and 11 months after diagnosis (mean 4.9 months). Initial determinations of IGF-I, 24-h urine C-peptide and microalbuminuria, age, sex, height, weight, body mass index, pubertal stage, and glycosylated hemoglobin (GHb) were obtained. IGF-I levels ranged from 11-439 ng/mL, were strongly related to age (r = 0.74, P < 0.001), and were higher in females than males at any given age (P < 0.01). IGF-I was inversely related to GHb (partial r = -0.43, P < 0.001) after adjustment for sex and age. The relationship between IGF-I and GHb did not change between age groups (< 6, 6-9, > or = 10 yr of age; P = 0.50), and it did not change between prepubertal and pubertal subjects (P = 0.95). IGF-I was not related to 24-h urine C-peptide or microalbuminuria. These results suggest that lower IGF-I levels are related to poorer metabolic control of diabetes in the period following insulin-dependent diabetes mellitus diagnosis in all young persons regardless of age or pubertal status.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0021-972X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
80
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2139-43
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:7608267-Adolescent,
pubmed-meshheading:7608267-Age Factors,
pubmed-meshheading:7608267-Albuminuria,
pubmed-meshheading:7608267-Blood Glucose,
pubmed-meshheading:7608267-Body Mass Index,
pubmed-meshheading:7608267-C-Peptide,
pubmed-meshheading:7608267-Child,
pubmed-meshheading:7608267-Cohort Studies,
pubmed-meshheading:7608267-Diabetes Mellitus, Type 1,
pubmed-meshheading:7608267-Female,
pubmed-meshheading:7608267-Hemoglobin A, Glycosylated,
pubmed-meshheading:7608267-Humans,
pubmed-meshheading:7608267-Insulin-Like Growth Factor I,
pubmed-meshheading:7608267-Male,
pubmed-meshheading:7608267-Puberty,
pubmed-meshheading:7608267-Radioimmunoassay,
pubmed-meshheading:7608267-Sex Characteristics,
pubmed-meshheading:7608267-Sex Factors,
pubmed-meshheading:7608267-Time Factors
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Insulin-like growth factor-I is related to glycemic control in children and adolescents with newly diagnosed insulin-dependent diabetes.
|
| pubmed:affiliation |
Department of Medicine, University of Wisconsin School of Medicine, Madison 53792, USA.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
|