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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1979-4-25
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pubmed:abstractText |
It has been proposed that I-cell disease results from a primary deficiency of acid neuraminidase activity. Infection by influenza virus of fibroblasts from a patient with I-cell disease resulted in the production of abundant intracellular alpha2-3 neuraminidase activity. Despite electrophoretic evidence of desialylation of intracellular and fibroblast-secreted arylsulfatase (EC 3.1.6.1) and beta-hexosaminidase (EC 3.2.1.30) from the infected cells, there was no consequent alteration of the abnormal distribution of beta-hexosaminidase activity between the intracellular spaces characteristic of I-cell disease. This suggests that deficiency of alpha2,3 neuraminidase activity is not the primary biochemical defect in I-cell disease.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0006-3002
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
4
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pubmed:volume |
582
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
164-71
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:760815-Arylsulfatases,
pubmed-meshheading:760815-Cell Transformation, Viral,
pubmed-meshheading:760815-Cells, Cultured,
pubmed-meshheading:760815-Fibroblasts,
pubmed-meshheading:760815-Hexosaminidases,
pubmed-meshheading:760815-Humans,
pubmed-meshheading:760815-Influenza A virus,
pubmed-meshheading:760815-Lysosomes,
pubmed-meshheading:760815-Mucolipidoses,
pubmed-meshheading:760815-Neuraminidase,
pubmed-meshheading:760815-Sialic Acids
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pubmed:year |
1979
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pubmed:articleTitle |
I-cell disease: intracellular desialylation of lysosomal enzymes using an influenza virus vector.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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