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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1995-8-15
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pubmed:databankReference |
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pubmed:abstractText |
Osteoglycin (OG) is a glycoprotein that was first isolated from bovine bone. The deduced amino acid (aa) sequence from the cDNA analysis showed that a precursor of OG has consensus leucine-rich repeats. In this study, we have isolated from a mouse limb-bud library cDNA clones encoding a 298-aa OG. This molecule shows 85 and 86% homology to human and bovine OG, respectively. Furthermore, the C-terminal two-thirds of the protein shows 48% homology to the corresponding portion of chick proteoglycan (PG)-Lb, a PG that has been shown to be preferentially expressed in the zone of flattened chondrocytes in the developing limb cartilage. Northern blot analysis of various mouse tissues revealed a 3.7-kb transcript in a limited number of these tissues.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0378-1119
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
9
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pubmed:volume |
158
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
237-40
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:7607548-Amino Acid Sequence,
pubmed-meshheading:7607548-Animals,
pubmed-meshheading:7607548-Avian Proteins,
pubmed-meshheading:7607548-Base Sequence,
pubmed-meshheading:7607548-Blotting, Northern,
pubmed-meshheading:7607548-Blotting, Southern,
pubmed-meshheading:7607548-Chondroitin Sulfate Proteoglycans,
pubmed-meshheading:7607548-DNA, Complementary,
pubmed-meshheading:7607548-Dermatan Sulfate,
pubmed-meshheading:7607548-Extremities,
pubmed-meshheading:7607548-Genomic Library,
pubmed-meshheading:7607548-Glycoproteins,
pubmed-meshheading:7607548-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:7607548-Mice,
pubmed-meshheading:7607548-Molecular Sequence Data,
pubmed-meshheading:7607548-Proteoglycans,
pubmed-meshheading:7607548-Sequence Homology, Amino Acid,
pubmed-meshheading:7607548-Species Specificity
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pubmed:year |
1995
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pubmed:articleTitle |
Molecular cloning of the mouse osteoglycin-encoding gene.
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pubmed:affiliation |
Institute for Molecular Science of Medicine, Aichi Medical University, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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