| pubmed-article:7607321 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7607321 | lifeskim:mentions | umls-concept:C0044602 | lld:lifeskim |
| pubmed-article:7607321 | lifeskim:mentions | umls-concept:C0014139 | lld:lifeskim |
| pubmed-article:7607321 | lifeskim:mentions | umls-concept:C1704353 | lld:lifeskim |
| pubmed-article:7607321 | lifeskim:mentions | umls-concept:C0205390 | lld:lifeskim |
| pubmed-article:7607321 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:7607321 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:7607321 | pubmed:dateCreated | 1995-8-17 | lld:pubmed |
| pubmed-article:7607321 | pubmed:abstractText | Endocytosis of the fluid phase marker, horse radish peroxidase, into baby hamster kidney cells is inhibited by treatment of cells with the fungal metabolite wortmannin. The IC50 of approximately 5 nM is consistent with the well-described action of wortmannin upon phosphatidylinositol (PI) 3-kinase. Analysis of the kinetics of uptake indicates a > 50% decrease in the initial rate of marker internalisation, a concomitant decrease in the volume of the early endosome and an increased efficiency of recycling of that marker which is internalised. As PI 3-kinase binds to activated growth factor receptors our data suggest that receptor activation can be coupled to receptor internalisation (down regulation) by localising PI 3-kinase stimulation of endocytosis. | lld:pubmed |
| pubmed-article:7607321 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7607321 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7607321 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7607321 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7607321 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7607321 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7607321 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7607321 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7607321 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:7607321 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:7607321 | pubmed:author | pubmed-author:ThorpeCC | lld:pubmed |
| pubmed-article:7607321 | pubmed:author | pubmed-author:JonesA TAT | lld:pubmed |
| pubmed-article:7607321 | pubmed:author | pubmed-author:ClagueM JMJ | lld:pubmed |
| pubmed-article:7607321 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7607321 | pubmed:day | 3 | lld:pubmed |
| pubmed-article:7607321 | pubmed:volume | 367 | lld:pubmed |
| pubmed-article:7607321 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7607321 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7607321 | pubmed:pagination | 272-4 | lld:pubmed |
| pubmed-article:7607321 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:7607321 | pubmed:meshHeading | pubmed-meshheading:7607321-... | lld:pubmed |
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| pubmed-article:7607321 | pubmed:meshHeading | pubmed-meshheading:7607321-... | lld:pubmed |
| pubmed-article:7607321 | pubmed:meshHeading | pubmed-meshheading:7607321-... | lld:pubmed |
| pubmed-article:7607321 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7607321 | pubmed:articleTitle | Phosphatidylinositol 3-kinase regulation of fluid phase endocytosis. | lld:pubmed |
| pubmed-article:7607321 | pubmed:affiliation | Physiological Laboratory, University of Liverpool, UK. | lld:pubmed |
| pubmed-article:7607321 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7607321 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:7607321 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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