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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1995-8-17
|
| pubmed:abstractText |
The neural cell adhesion molecule (NCAM) probably plays a role in neural plasticity in the adult vertebrate brain. We here present evidence that NCAM may be involved in long-term potentiation (LTP) in the CA1-region of rat hippocampal slices. It is shown that local application of antibodies against NCAM inhibits subsequent LTP-induction. Thus NCAM may be directly involved in the initial phase of LTP-induction. These results have important implications for the possible involvement of NCAM in learning and memory.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0006-8993
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
17
|
| pubmed:volume |
677
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
145-51
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7606459-2-Amino-5-phosphonovalerate,
pubmed-meshheading:7606459-Animals,
pubmed-meshheading:7606459-Antibodies,
pubmed-meshheading:7606459-Cell Adhesion Molecules, Neuronal,
pubmed-meshheading:7606459-Diffusion,
pubmed-meshheading:7606459-Hippocampus,
pubmed-meshheading:7606459-Immunohistochemistry,
pubmed-meshheading:7606459-Long-Term Potentiation,
pubmed-meshheading:7606459-Male,
pubmed-meshheading:7606459-Microinjections,
pubmed-meshheading:7606459-Neural Pathways,
pubmed-meshheading:7606459-Rats,
pubmed-meshheading:7606459-Rats, Wistar
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
NCAM-antibodies modulate induction of long-term potentiation in rat hippocampal CA1.
|
| pubmed:affiliation |
University of Copenhagen, Protein Laboratory, Panum Institute, Denmark.
|
| pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|