Linked Life Data

7606256

Source:http://linkedlifedata.com/resource/pubmed/id/7606256

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1995-8-11
pubmed:abstractText
Clusters of rat carotid body glomus cells were cultured for 1 to 12 days. Preparations were exposed to a control PO2 of 134.9 +/- 1.1 torr (mean +/- SE), and an external chloride activity, ao(Cl), of 105.6 +/- 2 mM. Thirty-six cells had a resting potential (Em) of -25.2 +/- 0.9 mV. The intracellular chloride activity, ai(Cl), was 32.8 +/- 1.1 mM, and the calculated chloride equilibrium potential (ECl) was -30.9 +/- 0.9 mV. ECl was more negative than Em, indicating that Cl- ions are not passively distributed. Hypoxia (5.4 +/- 0.8 torr), induced by Na-dithionite (Na2S2O4) 1.25 mM, elicited cell depolarization, increased ai(Cl) and a less negative ECl in about 80% of the cells. Fourteen per cent of the cells showed opposite effects. It is hypothesized that the increased ai(Cl) occurs because an outward-directed chloride pump is blocked by hypoxia. This effect is aided by depolarization of the cell. Decreased ai(Cl) may be due to cell hyperpolarization.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0716-9760
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
365-70
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Effect of hypoxia on the intracellular chloride activity of cultured glomus cells of the rat carotid body.
pubmed:affiliation
Department of Physiology, University of Utah School of Medicine, Salt Lake City 84108, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.