| pubmed-article:7605997 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7605997 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:7605997 | lifeskim:mentions | umls-concept:C0680220 | lld:lifeskim |
| pubmed-article:7605997 | lifeskim:mentions | umls-concept:C1518932 | lld:lifeskim |
| pubmed-article:7605997 | lifeskim:mentions | umls-concept:C0796355 | lld:lifeskim |
| pubmed-article:7605997 | lifeskim:mentions | umls-concept:C1961099 | lld:lifeskim |
| pubmed-article:7605997 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:7605997 | lifeskim:mentions | umls-concept:C1709305 | lld:lifeskim |
| pubmed-article:7605997 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:7605997 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:7605997 | pubmed:dateCreated | 1995-8-15 | lld:pubmed |
| pubmed-article:7605997 | pubmed:abstractText | Almost 25% of patients with T-cell acute lymphoblastic leukemia (T-ALL) have tumor-specific rearrangements of the TAL1 gene. Although TAL1 expression has not been observed in normal lymphocytes, TAL1 gene products are readily detected in leukemic cells that harbor a rearranged TAL1 allele. Hence, it has been proposed that ectopic expression of TAL1 promotes the development of T-ALL. In this report, we show that TAL1 is expressed in the leukemic cells of most patients with T-ALL, including many that do not display an apparent TAL1 gene alteration. A polymorphic dinucleotide repeat in the transcribed sequences of TAL1 was used to determine the allele specificity of TAL1 transcription in primary T-ALL cells. Monoallelic expression of TAL1 was observed in the leukemic cells of all patients (8 of 8) bearing a TAL1 gene rearrangement. In the leukemic cells of patients without detectable TAL1 rearrangements, TAL1 transcription occurred in either a monoallelic (3 of 7 patients) or a biallelic (4 of 7 patients) fashion. Thus, TAL1 activation in these patients may result from subtle alterations in cis-acting regulatory sequences (affecting expression of a single TAL1 allele) or changes in trans-acting factors that control TAL1 transcription (affecting expression of both TAL1 alleles). | lld:pubmed |
| pubmed-article:7605997 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7605997 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7605997 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7605997 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7605997 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7605997 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:7605997 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7605997 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7605997 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7605997 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7605997 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7605997 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7605997 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7605997 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7605997 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:7605997 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:7605997 | pubmed:author | pubmed-author:SmithR GRG | lld:pubmed |
| pubmed-article:7605997 | pubmed:author | pubmed-author:BaerRR | lld:pubmed |
| pubmed-article:7605997 | pubmed:author | pubmed-author:CristW MWM | lld:pubmed |
| pubmed-article:7605997 | pubmed:author | pubmed-author:HallSS | lld:pubmed |
| pubmed-article:7605997 | pubmed:author | pubmed-author:TimmonsC FCF | lld:pubmed |
| pubmed-article:7605997 | pubmed:author | pubmed-author:CAMPP DPD | lld:pubmed |
| pubmed-article:7605997 | pubmed:author | pubmed-author:AmylonMM | lld:pubmed |
| pubmed-article:7605997 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7605997 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:7605997 | pubmed:volume | 86 | lld:pubmed |
| pubmed-article:7605997 | pubmed:geneSymbol | TAL1 | lld:pubmed |
| pubmed-article:7605997 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7605997 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7605997 | pubmed:pagination | 666-76 | lld:pubmed |
| pubmed-article:7605997 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:7605997 | pubmed:meshHeading | pubmed-meshheading:7605997-... | lld:pubmed |
| pubmed-article:7605997 | pubmed:meshHeading | pubmed-meshheading:7605997-... | lld:pubmed |
| pubmed-article:7605997 | pubmed:meshHeading | pubmed-meshheading:7605997-... | lld:pubmed |
| pubmed-article:7605997 | pubmed:meshHeading | pubmed-meshheading:7605997-... | lld:pubmed |
| pubmed-article:7605997 | pubmed:meshHeading | pubmed-meshheading:7605997-... | lld:pubmed |
| pubmed-article:7605997 | pubmed:meshHeading | pubmed-meshheading:7605997-... | lld:pubmed |
| pubmed-article:7605997 | pubmed:meshHeading | pubmed-meshheading:7605997-... | lld:pubmed |
| pubmed-article:7605997 | pubmed:meshHeading | pubmed-meshheading:7605997-... | lld:pubmed |
| pubmed-article:7605997 | pubmed:meshHeading | pubmed-meshheading:7605997-... | lld:pubmed |
| pubmed-article:7605997 | pubmed:meshHeading | pubmed-meshheading:7605997-... | lld:pubmed |
| pubmed-article:7605997 | pubmed:meshHeading | pubmed-meshheading:7605997-... | lld:pubmed |
| pubmed-article:7605997 | pubmed:meshHeading | pubmed-meshheading:7605997-... | lld:pubmed |
| pubmed-article:7605997 | pubmed:meshHeading | pubmed-meshheading:7605997-... | lld:pubmed |
| pubmed-article:7605997 | pubmed:meshHeading | pubmed-meshheading:7605997-... | lld:pubmed |
| pubmed-article:7605997 | pubmed:meshHeading | pubmed-meshheading:7605997-... | lld:pubmed |
| pubmed-article:7605997 | pubmed:meshHeading | pubmed-meshheading:7605997-... | lld:pubmed |
| pubmed-article:7605997 | pubmed:meshHeading | pubmed-meshheading:7605997-... | lld:pubmed |
| pubmed-article:7605997 | pubmed:meshHeading | pubmed-meshheading:7605997-... | lld:pubmed |
| pubmed-article:7605997 | pubmed:meshHeading | pubmed-meshheading:7605997-... | lld:pubmed |
| pubmed-article:7605997 | pubmed:meshHeading | pubmed-meshheading:7605997-... | lld:pubmed |
| pubmed-article:7605997 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7605997 | pubmed:articleTitle | Does activation of the TAL1 gene occur in a majority of patients with T-cell acute lymphoblastic leukemia? A pediatric oncology group study. | lld:pubmed |
| pubmed-article:7605997 | pubmed:affiliation | Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235-9048, USA. | lld:pubmed |
| pubmed-article:7605997 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7605997 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:7605997 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7605997 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:7605997 | pubmed:publicationType | Multicenter Study | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605997 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605997 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605997 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605997 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605997 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605997 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605997 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605997 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605997 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605997 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605997 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605997 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605997 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605997 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605997 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605997 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605997 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605997 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605997 | lld:pubmed |
