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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1995-8-15
|
| pubmed:abstractText |
Almost 25% of patients with T-cell acute lymphoblastic leukemia (T-ALL) have tumor-specific rearrangements of the TAL1 gene. Although TAL1 expression has not been observed in normal lymphocytes, TAL1 gene products are readily detected in leukemic cells that harbor a rearranged TAL1 allele. Hence, it has been proposed that ectopic expression of TAL1 promotes the development of T-ALL. In this report, we show that TAL1 is expressed in the leukemic cells of most patients with T-ALL, including many that do not display an apparent TAL1 gene alteration. A polymorphic dinucleotide repeat in the transcribed sequences of TAL1 was used to determine the allele specificity of TAL1 transcription in primary T-ALL cells. Monoallelic expression of TAL1 was observed in the leukemic cells of all patients (8 of 8) bearing a TAL1 gene rearrangement. In the leukemic cells of patients without detectable TAL1 rearrangements, TAL1 transcription occurred in either a monoallelic (3 of 7 patients) or a biallelic (4 of 7 patients) fashion. Thus, TAL1 activation in these patients may result from subtle alterations in cis-acting regulatory sequences (affecting expression of a single TAL1 allele) or changes in trans-acting factors that control TAL1 transcription (affecting expression of both TAL1 alleles).
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Basic Helix-Loop-Helix...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/TAL1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0006-4971
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
86
|
| pubmed:geneSymbol |
TAL1
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
666-76
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7605997-Alleles,
pubmed-meshheading:7605997-Base Sequence,
pubmed-meshheading:7605997-Basic Helix-Loop-Helix Transcription Factors,
pubmed-meshheading:7605997-Bone Marrow,
pubmed-meshheading:7605997-Burkitt Lymphoma,
pubmed-meshheading:7605997-Child,
pubmed-meshheading:7605997-DNA, Neoplasm,
pubmed-meshheading:7605997-DNA-Binding Proteins,
pubmed-meshheading:7605997-Gene Expression Regulation, Leukemic,
pubmed-meshheading:7605997-Gene Rearrangement,
pubmed-meshheading:7605997-Humans,
pubmed-meshheading:7605997-Leukemia-Lymphoma, Adult T-Cell,
pubmed-meshheading:7605997-Molecular Sequence Data,
pubmed-meshheading:7605997-Neoplasm Proteins,
pubmed-meshheading:7605997-Neoplastic Stem Cells,
pubmed-meshheading:7605997-Pleural Effusion,
pubmed-meshheading:7605997-Polymerase Chain Reaction,
pubmed-meshheading:7605997-Proto-Oncogene Proteins,
pubmed-meshheading:7605997-T-Lymphocytes,
pubmed-meshheading:7605997-Transcription Factors
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Does activation of the TAL1 gene occur in a majority of patients with T-cell acute lymphoblastic leukemia? A pediatric oncology group study.
|
| pubmed:affiliation |
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235-9048, USA.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Multicenter Study
|