Linked Life Data

7605379

Source:http://linkedlifedata.com/resource/pubmed/id/7605379

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1995-8-10
pubmed:abstractText
In several populations, the apolipoprotein E (apo E) allele epsilon 4 is associated with high concentration of plasma total and low density lipoprotein (LDL)-cholesterol and coronary artery disease (CAD). We determined the apo E phenotypes of 309 patients with angiographically verified CAD and 38 patients without CAD by isoelectric focusing and Western blotting. In men with CAD, the plasma total and LDL-cholesterol increased according to apo E phenotype in the following order: E3/2 < E3/3 < E4/3 < E4/4 (P = 0.03 for total cholesterol, P = 0.007 for LDL-cholesterol). In women, there was a similar trend (P = 0.22 for total cholesterol, P = 0.15 for LDL-cholesterol). The relative frequency of men with three vessel CAD increased (P = 0.43) together with LDL-cholesterol levels (P = 0.05) according to apo E phenotype E3/2, E3/3, E4/3, E4/4. Total and LDL-cholesterol levels were higher in patients with three vessel CAD than in patients with less serious types of CAD (P = 0.02 for total cholesterol, P = 0.007 for LDL-cholesterol). The relative frequency of patients with myocardial infarction increased according to apo E phenotype (P = 0.51). Both in men and women, there were no differences between apo E phenotypes in age at occurrence of the first myocardial infarction. The apo E allele frequencies of patients with CAD vs. without CAD were 2.3% vs. 1.3% for epsilon 2, 79.0% vs. 76.3% for epsilon 3 and 18.7% vs. 22.4% for epsilon 4. There were no statistically significant differences in apo E allele or phenotype frequencies between patients with CAD and without CAD or between patients with CAD and the general Finnish population. Our results support previous studies in suggesting that the apo E allele epsilon 4 is a risk factor for atherosclerosis, which affects plasma total and LDL-cholesterol. In addition, our results suggest that the apo E allele determines the severity of CAD.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0021-9150
pubmed:author
pubmed:issnType
Print
pubmed:day
7
pubmed:volume
114
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
83-91
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:7605379-Age Distribution, pubmed-meshheading:7605379-Aged, pubmed-meshheading:7605379-Alleles, pubmed-meshheading:7605379-Analysis of Variance, pubmed-meshheading:7605379-Apolipoproteins E, pubmed-meshheading:7605379-Cholesterol, pubmed-meshheading:7605379-Cholesterol, HDL, pubmed-meshheading:7605379-Cholesterol, LDL, pubmed-meshheading:7605379-Coronary Angiography, pubmed-meshheading:7605379-Coronary Disease, pubmed-meshheading:7605379-Female, pubmed-meshheading:7605379-Humans, pubmed-meshheading:7605379-Lipids, pubmed-meshheading:7605379-Male, pubmed-meshheading:7605379-Middle Aged, pubmed-meshheading:7605379-Myocardial Infarction, pubmed-meshheading:7605379-Polymorphism, Genetic, pubmed-meshheading:7605379-Risk Factors, pubmed-meshheading:7605379-Severity of Illness Index, pubmed-meshheading:7605379-Sex Distribution, pubmed-meshheading:7605379-Triglycerides
pubmed:year
1995
pubmed:articleTitle
Apolipoprotein E polymorphism, serum lipids, myocardial infarction and severity of angiographically verified coronary artery disease in men and women.
pubmed:affiliation
Department of Biomedical Sciences, University of Tampere, Finland.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't