| pubmed-article:7604355 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7604355 | lifeskim:mentions | umls-concept:C0085080 | lld:lifeskim |
| pubmed-article:7604355 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:7604355 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:7604355 | lifeskim:mentions | umls-concept:C0002085 | lld:lifeskim |
| pubmed-article:7604355 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:7604355 | lifeskim:mentions | umls-concept:C1707329 | lld:lifeskim |
| pubmed-article:7604355 | lifeskim:mentions | umls-concept:C0336892 | lld:lifeskim |
| pubmed-article:7604355 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7604355 | pubmed:dateCreated | 1995-8-8 | lld:pubmed |
| pubmed-article:7604355 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7604355 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7604355 | pubmed:abstractText | RPE.40 mutant cells differ from wild-type Chinese hamster ovary (CHO-K1) cells in their increased resistance to Pseudomonas exotoxin A and their inability to process the insulin proreceptor and certain viral envelope proproteins. Northern analysis revealed that RPE.40 cells maintained a substantially lower steady-state level of 4.0 kb fur mRNA than did CHO-K1 cells. Analysis of fur cDNAs showed that RPE.40 cells were diploid at the fur locus, and RPE.40 cells had a Cys (TGC) to Tyr (TAC) mutation in codon 196 of one allele (allele I). Approximately 25-30% of the CHO-K1 cells were also heterozygous (Tyr/Cys) at codon 196, and pre-mRNAs transcribed from the second allele (allele II) in RPE.40 cells were defectively spliced. All other pre-mRNAs were correctly spliced. Rapid turnover of defectively spliced transcripts may account for the reduced steady-state level of fur mRNA observed in RPE.40 cells. Our results provide a mechanistic basis for the endoprotease-deficient phenotype of RPE.40 cells. | lld:pubmed |
| pubmed-article:7604355 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7604355 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7604355 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7604355 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7604355 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7604355 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7604355 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7604355 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7604355 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7604355 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:7604355 | pubmed:issn | 0740-7750 | lld:pubmed |
| pubmed-article:7604355 | pubmed:author | pubmed-author:MoehringT JTJ | lld:pubmed |
| pubmed-article:7604355 | pubmed:author | pubmed-author:SucicJ FJF | lld:pubmed |
| pubmed-article:7604355 | pubmed:author | pubmed-author:FoleyB TBT | lld:pubmed |
| pubmed-article:7604355 | pubmed:author | pubmed-author:SpenceM JMJ | lld:pubmed |
| pubmed-article:7604355 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7604355 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:7604355 | pubmed:geneSymbol | fur | lld:pubmed |
| pubmed-article:7604355 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7604355 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7604355 | pubmed:pagination | 1-18 | lld:pubmed |
| pubmed-article:7604355 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:7604355 | pubmed:meshHeading | pubmed-meshheading:7604355-... | lld:pubmed |
| pubmed-article:7604355 | pubmed:meshHeading | pubmed-meshheading:7604355-... | lld:pubmed |
| pubmed-article:7604355 | pubmed:meshHeading | pubmed-meshheading:7604355-... | lld:pubmed |
| pubmed-article:7604355 | pubmed:meshHeading | pubmed-meshheading:7604355-... | lld:pubmed |
| pubmed-article:7604355 | pubmed:meshHeading | pubmed-meshheading:7604355-... | lld:pubmed |
| pubmed-article:7604355 | pubmed:meshHeading | pubmed-meshheading:7604355-... | lld:pubmed |
| pubmed-article:7604355 | pubmed:meshHeading | pubmed-meshheading:7604355-... | lld:pubmed |
| pubmed-article:7604355 | pubmed:meshHeading | pubmed-meshheading:7604355-... | lld:pubmed |
| pubmed-article:7604355 | pubmed:meshHeading | pubmed-meshheading:7604355-... | lld:pubmed |
| pubmed-article:7604355 | pubmed:meshHeading | pubmed-meshheading:7604355-... | lld:pubmed |
| pubmed-article:7604355 | pubmed:meshHeading | pubmed-meshheading:7604355-... | lld:pubmed |
| pubmed-article:7604355 | pubmed:meshHeading | pubmed-meshheading:7604355-... | lld:pubmed |
| pubmed-article:7604355 | pubmed:meshHeading | pubmed-meshheading:7604355-... | lld:pubmed |
| pubmed-article:7604355 | pubmed:meshHeading | pubmed-meshheading:7604355-... | lld:pubmed |
| pubmed-article:7604355 | pubmed:meshHeading | pubmed-meshheading:7604355-... | lld:pubmed |
| pubmed-article:7604355 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7604355 | pubmed:articleTitle | Analysis of mutations in alleles of the fur gene from an endoprotease-deficient Chinese hamster ovary cell strain. | lld:pubmed |
| pubmed-article:7604355 | pubmed:affiliation | Department of Microbiology and Molecular Genetics, Markey Center for Molecular Genetics, Burlington, Vermont 05405, USA. | lld:pubmed |
| pubmed-article:7604355 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7604355 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7604355 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:100682534 | entrezgene:pubmed | pubmed-article:7604355 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7604355 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7604355 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7604355 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7604355 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7604355 | lld:pubmed |
