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rdf:type |
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lifeskim:mentions |
umls-concept:C0018270,
umls-concept:C0018284,
umls-concept:C0027651,
umls-concept:C0035647,
umls-concept:C0035820,
umls-concept:C0039194,
umls-concept:C0221920,
umls-concept:C0332448,
umls-concept:C0380603,
umls-concept:C1521733,
umls-concept:C2936350
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pubmed:issue |
14
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pubmed:dateCreated |
1995-8-10
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pubmed:abstractText |
Despite significant infiltration into tumors and atherosclerotic plaques, the role of T lymphocytes in these pathological conditions is still unclear. We have demonstrated that tumor-infiltrating lymphocytes (TILs) and plaque-infiltrating lymphocytes (PILs) produce heparin-binding epidermal growth factor-like growth factor (HB-EGF) and basic fibroblast growth factor (bFGF) in vitro under nonspecific conditions and in vivo in tumors by immunohistochemical staining. HB-EGF and bFGF derived from TILs and PILs directly stimulated tumor cells and vascular smooth muscle cells (SMCs) in vitro, respectively, while bFGF displayed angiogenic properties. Therefore, T cells may play a critical role in the SMC hyperplasia of atherosclerosis and support tumor progression by direct stimulation and angiogenesis.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604030-1309590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604030-1689143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604030-1826109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604030-1840698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604030-2023924,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604030-2072662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604030-2088527,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604030-2107973,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604030-2343305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604030-2432664,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604030-2549857,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604030-2684393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604030-2787872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604030-3063267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604030-3257584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604030-3257650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604030-3262710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604030-7909156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604030-8228240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604030-8302833,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604030-8313380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604030-8362977,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604030-8418301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604030-8420675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604030-8453790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604030-8479518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604030-8483908
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6547-51
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7604030-3T3 Cells,
pubmed-meshheading:7604030-Animals,
pubmed-meshheading:7604030-Arteriosclerosis,
pubmed-meshheading:7604030-Biological Assay,
pubmed-meshheading:7604030-Breast Neoplasms,
pubmed-meshheading:7604030-Cell Division,
pubmed-meshheading:7604030-Chromatography, Affinity,
pubmed-meshheading:7604030-Epidermal Growth Factor,
pubmed-meshheading:7604030-Female,
pubmed-meshheading:7604030-Fibroblast Growth Factor 2,
pubmed-meshheading:7604030-Heparin,
pubmed-meshheading:7604030-Humans,
pubmed-meshheading:7604030-Immunohistochemistry,
pubmed-meshheading:7604030-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:7604030-Lymphocytes, Tumor-Infiltrating,
pubmed-meshheading:7604030-Mice,
pubmed-meshheading:7604030-Ovarian Neoplasms,
pubmed-meshheading:7604030-T-Lymphocytes
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pubmed:year |
1995
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pubmed:articleTitle |
T lymphocytes that infiltrate tumors and atherosclerotic plaques produce heparin-binding epidermal growth factor-like growth factor and basic fibroblast growth factor: a potential pathologic role.
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pubmed:affiliation |
Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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