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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1995-8-10
|
| pubmed:abstractText |
In late 1990, it became standard practice at the palliative care unit of the Edmonton General Hospital to regularly administer the Mini-Mental State Questionnaire (MMSQ) and to undertake opioid rotation and hydration upon detection of cognitive failure. We retrospectively reviewed the charts of 117 and 162 patients admitted in 1988-1989 and 1991-1992, respectively, to assess the impact of these maneuvers on the prevalence of agitated impaired mental status (IMS). All patients underwent regular cognitive assessment in 1991-1992 versus none in 1988-1989. Seventy-three percent of patients received hydration in the second period versus 32% in the first (P < 0.01). The frequency of opioid rotation was also greater in the second period (41% versus 21%, P < 0.001). The incidence of agitated IMS decreased from 26% in 1988-1989 to 10% in 1991-1992 (P < 0.001). This was reflected by a lower mean dose of the major drug used to treat this condition, haloperidol (3.6 +/- 2.4 versus 5.6 +/- 3.8 mg/day, P < 0.01), and less frequent use of other neuroleptics and benzodiazepines (0.12 versus 0.38 prescriptions per patient, P < 0.01) in the second period. Our data suggest that routine cognitive monitoring, opioid rotation, and hydration may reduce the incidence of agitated IMS in terminal cancer patients.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0885-3924
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
10
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
287-91
|
| pubmed:dateRevised |
2006-8-15
|
| pubmed:meshHeading |
pubmed-meshheading:7602179-Aged,
pubmed-meshheading:7602179-Cognition,
pubmed-meshheading:7602179-Delirium,
pubmed-meshheading:7602179-Female,
pubmed-meshheading:7602179-Fluid Therapy,
pubmed-meshheading:7602179-Humans,
pubmed-meshheading:7602179-Male,
pubmed-meshheading:7602179-Middle Aged,
pubmed-meshheading:7602179-Narcotics,
pubmed-meshheading:7602179-Neoplasms,
pubmed-meshheading:7602179-Retrospective Studies
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Changing pattern of agitated impaired mental status in patients with advanced cancer: association with cognitive monitoring, hydration, and opioid rotation.
|
| pubmed:affiliation |
Palliative Care Program, Edmonton General Hospital, Alberta, Canada.
|
| pubmed:publicationType |
Journal Article
|