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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1995-8-7
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pubmed:databankReference |
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pubmed:abstractText |
We describe the isolation of a cDNA that encodes human lymphotactin (Ltn), a new class of lymphocyte-specific chemokine. Human Ltn shows similarity to some members of the C-C chemokine family but has lost the first and third cysteine residues that are characteristic of the C-C and C-X-C chemokines. Ltn is chemotactic for lymphocytes but not for monocytes, a characteristic that makes it unique among chemokines. In addition, calcium flux desensitization studies indicate that Ltn uses a unique receptor. The human Ltn gene maps to a different chromosome than do the C-C and C-X-C chemokine families. Taken together, these characteristics indicate that Ltn is the first example of a new class of human chemokines with preferential effects on lymphocytes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, C,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphokines,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Sialoglycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/XCL1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/lymphotactin
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
155
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pubmed:geneSymbol |
Ltn
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
203-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7602097-Amino Acid Sequence,
pubmed-meshheading:7602097-Base Sequence,
pubmed-meshheading:7602097-Blotting, Northern,
pubmed-meshheading:7602097-Blotting, Southern,
pubmed-meshheading:7602097-Calcium,
pubmed-meshheading:7602097-Chemokines, C,
pubmed-meshheading:7602097-Chemotaxis, Leukocyte,
pubmed-meshheading:7602097-Chromosome Mapping,
pubmed-meshheading:7602097-Cloning, Molecular,
pubmed-meshheading:7602097-Gene Library,
pubmed-meshheading:7602097-Humans,
pubmed-meshheading:7602097-Lymphokines,
pubmed-meshheading:7602097-Molecular Sequence Data,
pubmed-meshheading:7602097-RNA, Messenger,
pubmed-meshheading:7602097-Recombinant Proteins,
pubmed-meshheading:7602097-Sialoglycoproteins,
pubmed-meshheading:7602097-T-Lymphocyte Subsets,
pubmed-meshheading:7602097-Thymus Gland
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pubmed:year |
1995
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pubmed:articleTitle |
Molecular cloning and functional characterization of human lymphotactin.
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pubmed:affiliation |
Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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