|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0011015,
umls-concept:C0017258,
umls-concept:C0040649,
umls-concept:C0079429,
umls-concept:C0205087,
umls-concept:C0205245,
umls-concept:C0220781,
umls-concept:C0936012,
umls-concept:C0995786,
umls-concept:C1261552,
umls-concept:C1880022
|
|
pubmed:issue |
13
|
|
pubmed:dateCreated |
1995-8-4
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
Sequence analysis of the Streptomyces peucetius daunorubicin biosynthetic gene cluster revealed a partial (dnrQ) and two complete (dnrD and dnrP) open reading frames flanking dnrK. Bioconversion experiments showed that DnrD converts aklanonic acid methylester to aklaviketone and that DnrC is a methyltransferase that converts aklanonic acid to aklanonic acid methylester. The deduced dnrP gene product, homologous to known esterases, may catalyze the conversion of 10-carbomethoxy-13-deoxycarminomycin to its 10-carboxy derivative. The dnrKPQS genes may be transcribed as a polycistronic mRNA.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7601857-1549509,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7601857-1729206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7601857-1867849,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7601857-1924314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7601857-1989978,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7601857-2017360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7601857-2681140,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7601857-2681144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7601857-2684970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7601857-2985470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7601857-3171921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7601857-3859358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7601857-6546423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7601857-6631413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7601857-7764202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7601857-7764683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7601857-7828855,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7601857-7836284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7601857-7868593,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7601857-7868594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7601857-7928998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7601857-8232204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7601857-8334166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7601857-8436560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7601857-8509343
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DauP protein, Streptomyces,
http://linkedlifedata.com/resource/pubmed/chemical/Daunorubicin,
http://linkedlifedata.com/resource/pubmed/chemical/DnrQ protein, Streptomyces peucetius,
http://linkedlifedata.com/resource/pubmed/chemical/Esterases,
http://linkedlifedata.com/resource/pubmed/chemical/Isomerases,
http://linkedlifedata.com/resource/pubmed/chemical/Methyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/aklanonic acid methyl ester cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/aklanonic acid methyltransferase
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0021-9193
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
177
|
|
pubmed:geneSymbol |
dnrC,
dnrD,
dnrK,
dnrP,
dnrQ,
dnrS
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
3879-84
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:7601857-Amino Acid Sequence,
pubmed-meshheading:7601857-Bacterial Proteins,
pubmed-meshheading:7601857-Base Sequence,
pubmed-meshheading:7601857-Cloning, Molecular,
pubmed-meshheading:7601857-Daunorubicin,
pubmed-meshheading:7601857-Esterases,
pubmed-meshheading:7601857-Genes, Bacterial,
pubmed-meshheading:7601857-Isomerases,
pubmed-meshheading:7601857-Methyltransferases,
pubmed-meshheading:7601857-Molecular Sequence Data,
pubmed-meshheading:7601857-Multigene Family,
pubmed-meshheading:7601857-RNA, Messenger,
pubmed-meshheading:7601857-Restriction Mapping,
pubmed-meshheading:7601857-Sequence Analysis, DNA,
pubmed-meshheading:7601857-Streptomyces,
pubmed-meshheading:7601857-Transcription, Genetic
|
|
pubmed:year |
1995
|
|
pubmed:articleTitle |
Functional characterization and transcriptional analysis of a gene cluster governing early and late steps in daunorubicin biosynthesis in Streptomyces peucetius.
|
|
pubmed:affiliation |
School of Pharmacy, University of Wisconsin, Madison 53706, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
