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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1995-8-10
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pubmed:abstractText |
Oct-2, a POU homeodomain protein expressed primarily in B cells, is a powerful transcriptional activator that binds to DNA at sites appropriately placed for major effects on immunoglobulin gene expression. Our examination of B cell development and function in Oct-2 null mice did not support an essential role for Oct-2 early in B cell development. Rather, Oct-2 was required later, when B cells were induced to differentiate to antibody-secreting cells. We show here that Oct-2 is not required for normal immunoglobulin production by mature B lymphocytes. Instead, it is essential for a normal proliferative response to polyclonal mitogens. Responses to signals from activated T cells are unaffected. The requirement for Oct-2 maps to an early activation step in G1, during which B cells make the commitment to progress through the cell cycle and to divide.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1074-7613
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
635-45
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7600291-Animals,
pubmed-meshheading:7600291-Antibody-Producing Cells,
pubmed-meshheading:7600291-Antigens, Differentiation, B-Lymphocyte,
pubmed-meshheading:7600291-B-Lymphocytes,
pubmed-meshheading:7600291-Bone Marrow,
pubmed-meshheading:7600291-Cell Differentiation,
pubmed-meshheading:7600291-DNA-Binding Proteins,
pubmed-meshheading:7600291-G1 Phase,
pubmed-meshheading:7600291-Immunoglobulin Isotypes,
pubmed-meshheading:7600291-Immunotherapy, Adoptive,
pubmed-meshheading:7600291-Lymphocyte Activation,
pubmed-meshheading:7600291-Lymphocyte Cooperation,
pubmed-meshheading:7600291-Mice,
pubmed-meshheading:7600291-Mice, SCID,
pubmed-meshheading:7600291-Mutagenesis, Insertional,
pubmed-meshheading:7600291-Octamer Transcription Factor-2,
pubmed-meshheading:7600291-Transcription Factors
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pubmed:year |
1994
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pubmed:articleTitle |
Oct-2 is required early in T cell-independent B cell activation for G1 progression and for proliferation.
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pubmed:affiliation |
Walter and Eliza Hall Institute of Medical Research Post Office, Royal Melbourne Hospital, Victoria, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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