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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1979-3-24
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pubmed:abstractText |
The administration of cephradine prophylactically to patients who were undergoing vaginal hysterectomies resulted in a marked and significant reduction in the incidence of postoperative infections when compared to a placebo group. Cephradine was the cephalosporin studied because of its unique pharmacodynamic properties, which result in high uterine tissue levels. The protective effect was similar whether 1 g was given preoperatively followed by 500 mg IV q. 6 hours for 4 doses, or a single dose of 2 g IV given approximately 1 hour before surgery. Uterine tissue and serum levels of antibiotic were high and correlated with the degree of protection noted.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0029-7844
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
31-5
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pubmed:dateRevised |
2009-10-26
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pubmed:meshHeading |
pubmed-meshheading:760017-Adult,
pubmed-meshheading:760017-Aged,
pubmed-meshheading:760017-Bacterial Infections,
pubmed-meshheading:760017-Bacteriuria,
pubmed-meshheading:760017-Cephalosporins,
pubmed-meshheading:760017-Cephradine,
pubmed-meshheading:760017-Double-Blind Method,
pubmed-meshheading:760017-Female,
pubmed-meshheading:760017-Fever,
pubmed-meshheading:760017-Humans,
pubmed-meshheading:760017-Hysterectomy,
pubmed-meshheading:760017-Hysterectomy, Vaginal,
pubmed-meshheading:760017-Middle Aged,
pubmed-meshheading:760017-Pelvis,
pubmed-meshheading:760017-Placebos,
pubmed-meshheading:760017-Postoperative Complications,
pubmed-meshheading:760017-Prospective Studies,
pubmed-meshheading:760017-Urinary Tract Infections,
pubmed-meshheading:760017-Uterus
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pubmed:year |
1979
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pubmed:articleTitle |
Effect of single and multidose cephradine prophylaxis on infectious morbidity of vaginal hysterectomy.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Controlled Clinical Trial
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