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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1995-8-3
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pubmed:abstractText |
We have determined the nucleotide sequence of the HIV-1 vif gene in viruses obtained from symptomatic patients of distinct risk groups in Madrid. The genetic diversity among the isolates was estimated in 4.6% (+/- 1.4 standard deviation), a similar value to that obtained for the gag gene 3.9% (+/- 0.8 standard deviation) and env 4.1% (+/- 1 standard deviation) (Rojas et al., Virus Res 31, 331-342, 1994). Amino acid sequence analysis revealed the presence of hypermutable residues at positions 101 and 167, close to antigenically relevant sequential epitopes (comprising amino acids 87-94 and 172-178). Phylogenetic analysis supports the existence of two virus lineages circulating preferentially within different risk groups.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0920-8569
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:geneSymbol |
env,
gag,
vif
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
283-8
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:7597807-Adult,
pubmed-meshheading:7597807-Amino Acid Sequence,
pubmed-meshheading:7597807-Base Sequence,
pubmed-meshheading:7597807-Blood Transfusion,
pubmed-meshheading:7597807-Comorbidity,
pubmed-meshheading:7597807-Consensus Sequence,
pubmed-meshheading:7597807-Genes, vif,
pubmed-meshheading:7597807-Genetic Variation,
pubmed-meshheading:7597807-HIV Infections,
pubmed-meshheading:7597807-HIV-1,
pubmed-meshheading:7597807-Homosexuality,
pubmed-meshheading:7597807-Humans,
pubmed-meshheading:7597807-Infant, Newborn,
pubmed-meshheading:7597807-Molecular Sequence Data,
pubmed-meshheading:7597807-Phylogeny,
pubmed-meshheading:7597807-Risk Factors,
pubmed-meshheading:7597807-Sequence Alignment,
pubmed-meshheading:7597807-Sequence Homology, Nucleic Acid,
pubmed-meshheading:7597807-Spain,
pubmed-meshheading:7597807-Substance Abuse, Intravenous
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pubmed:year |
1995
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pubmed:articleTitle |
Sequence analysis of HIV-1 vif gene in Spanish isolates.
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pubmed:affiliation |
Centro Nacional de Biología Celular y Retrovirus, Instituto Carlos III, Majadahonda, Madrid, Spain.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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