Linked Life Data

7597551

Source:http://linkedlifedata.com/resource/pubmed/id/7597551

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1995-8-1
pubmed:abstractText
The lower esophageal sphincter provides a pressure barrier between the negative intrathoracic and positive intra-abdominal pressure environment. The resistance of the lower esophageal sphincter to reflux of gastric juice is determined by the integrated effects of radial pressures exerted over the entire length of the sphincter. This can be best quantitated by manometry with radially oriented pressure transducers and calculation of the SPVV (ie, the volume of the 3D sphincter pressure image). Validation studies have shown that the SPVV is superior to standard parameters of sphincter strength (ie, sphincter resting pressure, overall length, and abdominal length) and improves the identification of patients that will benefit from an anti-reflux procedure. This is particularly so in patients with subtle sphincter defects and patients with increased esophageal acid exposure and no mucosal injury on endoscopy. In addition, asymmetry of the sphincter that may contribute to incompetence of the cardia can only be detected by 3D manometric sphincter imaging. The effect of an anti-reflux procedure in controlling reflux is dependent on restoration of the defective 3D sphincter pressure image. Failure to do so is associated with recurrent or persistent reflux. 3D sphincter imaging can also illustrate the severely asymmetric and hypertensive sphincter in patients with achalasia and the effect of myotomy with or without a concomitant anti-reflux procedure on the sphincter pressure profile.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0081-9638
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
199-214
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Three-dimensional manometric imaging of the lower esophageal sphincter.
pubmed:affiliation
Chirurgische Klinik und Poliklinik der Technischen, Universität München, Germany.
pubmed:publicationType
Journal Article, Review