| pubmed-article:7596415 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7596415 | lifeskim:mentions | umls-concept:C0019764 | lld:lifeskim |
| pubmed-article:7596415 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:7596415 | lifeskim:mentions | umls-concept:C0680727 | lld:lifeskim |
| pubmed-article:7596415 | lifeskim:mentions | umls-concept:C0086168 | lld:lifeskim |
| pubmed-article:7596415 | pubmed:issue | 6534 | lld:pubmed |
| pubmed-article:7596415 | pubmed:dateCreated | 1995-8-3 | lld:pubmed |
| pubmed-article:7596415 | pubmed:abstractText | Human leukocyte antigen (HLA)-DM is an unconventional major histocompatibility complex (MHC) class II heterodimer that is important for B-cell-mediated antigen processing and presentation to MHC class II-restricted T cells. HLA-DM is encoded by two genes, DMA and DMB, which map to the MHC class II region, and shares some homology with MHC class I and class II proteins. Here we define the biochemical role of HLA-DM. Recombinant soluble HLA-DM heterodimers have been purified from culture supernatants of insect cell transformants. At pH 5.0, they induce the dissociation of a subset of peptides bound to HLA-DR, including a nested set of class-II-associated invariant chain peptides (CLIP). This process liberates HLA-DR and leads to the enhanced binding of exogenous peptides. | lld:pubmed |
| pubmed-article:7596415 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7596415 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7596415 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7596415 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7596415 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7596415 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7596415 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:7596415 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:7596415 | pubmed:author | pubmed-author:PorterGG | lld:pubmed |
| pubmed-article:7596415 | pubmed:author | pubmed-author:GammonMM | lld:pubmed |
| pubmed-article:7596415 | pubmed:author | pubmed-author:CameronPP | lld:pubmed |
| pubmed-article:7596415 | pubmed:author | pubmed-author:SloanV SVS | lld:pubmed |
| pubmed-article:7596415 | pubmed:author | pubmed-author:MellinsEE | lld:pubmed |
| pubmed-article:7596415 | pubmed:author | pubmed-author:ZallerD MDM | lld:pubmed |
| pubmed-article:7596415 | pubmed:author | pubmed-author:AmayaMM | lld:pubmed |
| pubmed-article:7596415 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7596415 | pubmed:day | 29 | lld:pubmed |
| pubmed-article:7596415 | pubmed:volume | 375 | lld:pubmed |
| pubmed-article:7596415 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7596415 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7596415 | pubmed:pagination | 802-6 | lld:pubmed |
| pubmed-article:7596415 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:7596415 | pubmed:meshHeading | pubmed-meshheading:7596415-... | lld:pubmed |
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| pubmed-article:7596415 | pubmed:meshHeading | pubmed-meshheading:7596415-... | lld:pubmed |
| pubmed-article:7596415 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7596415 | pubmed:articleTitle | Mediation by HLA-DM of dissociation of peptides from HLA-DR. | lld:pubmed |
| pubmed-article:7596415 | pubmed:affiliation | Department of Autoimmune Disease Research, Merck Research Laboratories, Rahway, New Jersey 07065, USA. | lld:pubmed |
| pubmed-article:7596415 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7596415 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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