Linked Life Data

7596305

Source:http://linkedlifedata.com/resource/pubmed/id/7596305

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1995-7-28
pubmed:abstractText
Ultraviolet B (UVB) radiation in sunlight damages the cutaneous immune system of individuals primarily by converting trans-urocanic acid (UCA) to its cis isoform which in turn instigates excessive local, and eventually systemic, levels of tumor necrosis factor-alpha (TNF alpha). UVB radiation and TNF alpha have been found to activate HIV from the latent state, and TNF alpha has been implicated in the pathogenesis of several manifestations of the acquired immune deficiency syndrome (AIDS). We hypothesize that the immunosuppressant properties of TNF alpha and cis-UCA, released by intense sun exposure, can accelerate the onset and progression of AIDS in HIV-infected individuals.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0306-9877
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
119-23
pubmed:dateRevised
2008-8-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Sunlight induced progression of AIDS.
pubmed:affiliation
Department of Microbiology and Immunology, University of Miami School of Medicine, FL 33101, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't