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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1995-8-3
|
| pubmed:abstractText |
In this paper we describe a patient with bcr/abl positive acute undifferentiated leukemia (AUL) derived from acquired sideroblastic anemia secondary to ifosphamide treatment given for the preceding non-Hodgkin lymphoma of the lung. Cytogenetically, Philadelphia chromosome was not detected through the whole course in this patient, and multiple chromosomal abnormalities including 5q- and monosomy 7 were found at the stage of sideroblastic anemia. The reverse transcriptase-polymerase chain reaction (RT-PCR) analysis showed no bcr/abl fusion transcript at the diagnosis of malignant lymphoma. The mRNA encoding the major bcr/abl fusion protein then appeared in the stage of sideroblastic anemia. Finally, the mRNA encoding both major and minor bcr/abl was detected in the stage of AUL transformation. MLL gene rearrangement was not found by RT-PCR analysis at any stage of the disorder. These results may be direct evidence for the induction of the bcr/abl fusion gene by treatment with an alkylating agent (ifosphamide).
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0145-2126
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
19
|
| pubmed:geneSymbol |
MLL
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
389-96
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:7596151-Acute Disease,
pubmed-meshheading:7596151-Alkylating Agents,
pubmed-meshheading:7596151-Anemia, Sideroblastic,
pubmed-meshheading:7596151-Base Sequence,
pubmed-meshheading:7596151-Cell Transformation, Neoplastic,
pubmed-meshheading:7596151-Chromosome Aberrations,
pubmed-meshheading:7596151-Chromosomes, Human, Pair 7,
pubmed-meshheading:7596151-Fusion Proteins, bcr-abl,
pubmed-meshheading:7596151-Gene Rearrangement,
pubmed-meshheading:7596151-Genes, abl,
pubmed-meshheading:7596151-Humans,
pubmed-meshheading:7596151-Ifosfamide,
pubmed-meshheading:7596151-Karyotyping,
pubmed-meshheading:7596151-Leukemia,
pubmed-meshheading:7596151-Male,
pubmed-meshheading:7596151-Middle Aged,
pubmed-meshheading:7596151-Molecular Sequence Data,
pubmed-meshheading:7596151-Monosomy,
pubmed-meshheading:7596151-Neoplasms, Second Primary,
pubmed-meshheading:7596151-Polymerase Chain Reaction,
pubmed-meshheading:7596151-RNA, Messenger,
pubmed-meshheading:7596151-Sensitivity and Specificity,
pubmed-meshheading:7596151-Transcription, Genetic
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Detection of major and minor bcr/abl fusion gene transcripts in a patient with acute undifferentiated leukemia secondary to treatment with an alkylating agent.
|
| pubmed:affiliation |
Nagoya National Hospital, Hematological Disease Center, Japan.
|
| pubmed:publicationType |
Journal Article,
Case Reports
|