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rdf:type |
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|
lifeskim:mentions |
|
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pubmed:issue |
10
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pubmed:dateCreated |
1995-12-4
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pubmed:abstractText |
An unusually high incidence of anaphylactoid reactions was observed during a phase I/II trial of high-dose intravenous cyclosporine (CsA) therapy to attenuate tumor multidrug resistance (MDR). Five of 21 children experienced severe anaphylactoid reactions shortly after initiation of the first or second CsA infusion. We hypothesized that improper dissolution of the vehicle Cremophor EL may have been a cause for these anaphylactoid reactions.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0732-183X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2508-16
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:7595701-Adolescent,
pubmed-meshheading:7595701-Anaphylaxis,
pubmed-meshheading:7595701-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:7595701-Azo Compounds,
pubmed-meshheading:7595701-Child,
pubmed-meshheading:7595701-Child, Preschool,
pubmed-meshheading:7595701-Cyclosporine,
pubmed-meshheading:7595701-Dose-Response Relationship, Drug,
pubmed-meshheading:7595701-Drug Resistance, Neoplasm,
pubmed-meshheading:7595701-Ethanol,
pubmed-meshheading:7595701-Glycerol,
pubmed-meshheading:7595701-Humans,
pubmed-meshheading:7595701-Immunosuppressive Agents,
pubmed-meshheading:7595701-Infusions, Intravenous,
pubmed-meshheading:7595701-Pharmaceutical Vehicles,
pubmed-meshheading:7595701-Premedication,
pubmed-meshheading:7595701-Rhabdomyosarcoma,
pubmed-meshheading:7595701-Solubility,
pubmed-meshheading:7595701-Solvents,
pubmed-meshheading:7595701-Statistics, Nonparametric
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pubmed:year |
1995
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pubmed:articleTitle |
Anaphylactoid reactions in children receiving high-dose intravenous cyclosporine for reversal of tumor resistance: the causative role of improper dissolution of Cremophor EL.
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pubmed:affiliation |
Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't,
Clinical Trial, Phase II,
Clinical Trial, Phase I
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