Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1995-12-4
pubmed:abstractText
The immune system can recognize differentiation antigens that are selectively expressed on malignant cells and their normal cell counterparts. However, it is uncertain whether immunity to differentiation antigens can effectively lead to tumor rejection. The mouse brown locus protein, gp75 or tyrosinase-related protein 1, is a melanocyte differentiation antigen expressed by melanomas and normal melanocytes. The gp75 antigen is recognized by autoantibodies and autoreactive T cells in persons with melanoma. To model autoimmunity against a melanocyte differentiation antigen, mouse antibodies against gp75 were passively transferred into tumor-bearing mice. Passive immunization with a mouse monoclonal antibody against gp75 induced protection and rejection of both subcutaneous tumors and lung metastases in syngeneic C57BL/6 mice, including established tumors. Passive immunity produced coat color alterations but only in regenerating hairs. This system provides a model for autoimmune vitiligo and shows that immune responses to melanocyte differentiation antigens can influence mouse coat color. Immune recognition of a melanocyte differentiation antigen can reject tumors, providing a basis for targeting tissue autoantigens expressed on cancer.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7595233-1292007, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595233-1725731, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595233-1794178, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595233-1924386, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595233-1985871, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595233-2324688, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595233-2674949, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595233-2700947, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595233-3132343, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595233-3132713, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595233-3280698, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595233-3473501, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595233-61813, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595233-6345714, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595233-6619553, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595233-6643767, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595233-7175440, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595233-7175442, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595233-7513441, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595233-7516926, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595233-7836932, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595233-7934446, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595233-8006576, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595233-8006593, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595233-8022805, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595233-8113668, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595233-8170934, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595233-8170938, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595233-8340755
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
182
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1609-14
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:7595233-Animals, pubmed-meshheading:7595233-Antibodies, Monoclonal, pubmed-meshheading:7595233-Antigens, Neoplasm, pubmed-meshheading:7595233-Autoantigens, pubmed-meshheading:7595233-Autoimmunity, pubmed-meshheading:7595233-Female, pubmed-meshheading:7595233-Graft Rejection, pubmed-meshheading:7595233-Hair Color, pubmed-meshheading:7595233-Immunotherapy, Adoptive, pubmed-meshheading:7595233-Killer Cells, Natural, pubmed-meshheading:7595233-Lung Neoplasms, pubmed-meshheading:7595233-Melanocytes, pubmed-meshheading:7595233-Melanoma, Experimental, pubmed-meshheading:7595233-Membrane Glycoproteins, pubmed-meshheading:7595233-Mice, pubmed-meshheading:7595233-Mice, Inbred C57BL, pubmed-meshheading:7595233-Neoplasm Proteins, pubmed-meshheading:7595233-Neoplasm Transplantation, pubmed-meshheading:7595233-Neoplasms, Experimental, pubmed-meshheading:7595233-Oxidoreductases, pubmed-meshheading:7595233-Skin Neoplasms, pubmed-meshheading:7595233-Vitiligo
pubmed:year
1995
pubmed:articleTitle
Implicating a role for immune recognition of self in tumor rejection: passive immunization against the brown locus protein.
pubmed:affiliation
Memorial Sloan-Kettering Cancer Center, New York 10021, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't