Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1995-12-4
pubmed:abstractText
During the inflammatory response, the adhesion molecule PECAM plays a crucial role in transendothelial migration, the passage of leukocytes across endothelium. We report here an additional role for PECAM in the subsequent migration of monocytes through the subendothelial extracellular matrix. PECAM has six immunoglobulin (Ig) superfamily domains. Monoclonal antibodies whose epitopes map to domains 1 and/or 2 selectively block monocyte migration through the endothelial junction, whereas those that map to domain 6 block only the migration through the extracellular matrix, trapping the monocyte between the endothelium and its basal lamina. Therefore, transendothelial migration (diapedesis) and passage through extracellular matrix (interstitial migration) are distinct and separable phases of monocyte emigration. Furthermore, distinct and separate Ig domains of PECAM are involved in mediating these two steps.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7595204-1281215, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595204-1377224, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595204-1377280, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595204-1380002, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595204-1512545, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595204-1569405, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595204-1689216, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595204-1690453, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595204-1874786, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595204-2078567, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595204-2666561, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595204-7505053, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595204-7513709, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595204-7521752, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595204-7528221, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595204-7538415, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595204-7687523, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595204-7995949, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595204-8113674, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595204-8248808, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595204-8294502, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595204-8340425, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595204-8340753, http://linkedlifedata.com/resource/pubmed/commentcorrection/7595204-8405046
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
182
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1337-43
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:7595204-Animals, pubmed-meshheading:7595204-Antibodies, Monoclonal, pubmed-meshheading:7595204-Antigens, CD31, pubmed-meshheading:7595204-Antigens, Differentiation, Myelomonocytic, pubmed-meshheading:7595204-Base Sequence, pubmed-meshheading:7595204-Cell Adhesion, pubmed-meshheading:7595204-Cell Adhesion Molecules, pubmed-meshheading:7595204-Cell Movement, pubmed-meshheading:7595204-Cells, Cultured, pubmed-meshheading:7595204-Cercopithecus aethiops, pubmed-meshheading:7595204-Endothelium, Vascular, pubmed-meshheading:7595204-Extracellular Matrix, pubmed-meshheading:7595204-Humans, pubmed-meshheading:7595204-Immunoglobulin G, pubmed-meshheading:7595204-Inflammation, pubmed-meshheading:7595204-Molecular Sequence Data, pubmed-meshheading:7595204-Monocytes, pubmed-meshheading:7595204-Protein Structure, Tertiary, pubmed-meshheading:7595204-Recombinant Fusion Proteins, pubmed-meshheading:7595204-Umbilical Veins
pubmed:year
1995
pubmed:articleTitle
Migration of monocytes across endothelium and passage through extracellular matrix involve separate molecular domains of PECAM-1.
pubmed:affiliation
Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York 10021-6399, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't