| pubmed-article:7594770 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7594770 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7594770 | lifeskim:mentions | umls-concept:C0036536 | lld:lifeskim |
| pubmed-article:7594770 | lifeskim:mentions | umls-concept:C0036537 | lld:lifeskim |
| pubmed-article:7594770 | lifeskim:mentions | umls-concept:C0030298 | lld:lifeskim |
| pubmed-article:7594770 | lifeskim:mentions | umls-concept:C0030274 | lld:lifeskim |
| pubmed-article:7594770 | lifeskim:mentions | umls-concept:C0037659 | lld:lifeskim |
| pubmed-article:7594770 | lifeskim:mentions | umls-concept:C0017687 | lld:lifeskim |
| pubmed-article:7594770 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:7594770 | lifeskim:mentions | umls-concept:C1549542 | lld:lifeskim |
| pubmed-article:7594770 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7594770 | pubmed:dateCreated | 1995-12-13 | lld:pubmed |
| pubmed-article:7594770 | pubmed:abstractText | The current study was undertaken to determine whether intraislet somatostatin regulates glucagon or pancreatic polypeptide (PP) secretion in the human pancreas. A high-affinity, high-specificity monoclonal somatostatin antibody (CURE.S6) was used to immunoneutralize somatostatin in the isolated, perfused human pancreas. Single-pass perfusion was performed in pancreata obtained from cadaveric organ donors using a modified Krebs media with either 3.9 or 12.9 mM glucose. Sequential test periods separated by basal periods were performed with infusion of either exogenous somatostatin-14 (SS-14), CURE.S6, or a combined infusion. Infusion of SS-14 did not significantly alter glucagon or PP secretion during low-glucose or high-glucose perfusion. Immunoneutralization of intraislet somatostatin with CURE.S6 resulted in a significant increase of glucagon secretion under low-glucose conditions (delta X = 15 +/- 3 pM) (p < 0.05), but did not significantly effect glucagon secretion under high-glucose conditions (delta X = -2 +/- 3 pM) (p = NS). PP secretion remained unchanged during CURE.S6 infusion. Combined infusion of SS-14 and CURE.S6 did not significantly alter glucagon or PP secretion. The data suggest that intraislet somatostatin may have an inhibitory role in the regulation of glucagon secretion during low-glucose conditions and that intraislet somatostatin does not regulate PP secretion in the isolated, perfused human pancreas. | lld:pubmed |
| pubmed-article:7594770 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7594770 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7594770 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7594770 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7594770 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7594770 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7594770 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7594770 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7594770 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7594770 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:7594770 | pubmed:issn | 0169-4197 | lld:pubmed |
| pubmed-article:7594770 | pubmed:author | pubmed-author:WalshJJ | lld:pubmed |
| pubmed-article:7594770 | pubmed:author | pubmed-author:KleinmanRR | lld:pubmed |
| pubmed-article:7594770 | pubmed:author | pubmed-author:WongHH | lld:pubmed |
| pubmed-article:7594770 | pubmed:author | pubmed-author:GingerichRR | lld:pubmed |
| pubmed-article:7594770 | pubmed:author | pubmed-author:OhningGG | lld:pubmed |
| pubmed-article:7594770 | pubmed:author | pubmed-author:BrunicardiF... | lld:pubmed |
| pubmed-article:7594770 | pubmed:author | pubmed-author:OlthoffKK | lld:pubmed |
| pubmed-article:7594770 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7594770 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:7594770 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7594770 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7594770 | pubmed:pagination | 51-7 | lld:pubmed |
| pubmed-article:7594770 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:7594770 | pubmed:meshHeading | pubmed-meshheading:7594770-... | lld:pubmed |
| pubmed-article:7594770 | pubmed:meshHeading | pubmed-meshheading:7594770-... | lld:pubmed |
| pubmed-article:7594770 | pubmed:meshHeading | pubmed-meshheading:7594770-... | lld:pubmed |
| pubmed-article:7594770 | pubmed:meshHeading | pubmed-meshheading:7594770-... | lld:pubmed |
| pubmed-article:7594770 | pubmed:meshHeading | pubmed-meshheading:7594770-... | lld:pubmed |
| pubmed-article:7594770 | pubmed:meshHeading | pubmed-meshheading:7594770-... | lld:pubmed |
| pubmed-article:7594770 | pubmed:meshHeading | pubmed-meshheading:7594770-... | lld:pubmed |
| pubmed-article:7594770 | pubmed:meshHeading | pubmed-meshheading:7594770-... | lld:pubmed |
| pubmed-article:7594770 | pubmed:meshHeading | pubmed-meshheading:7594770-... | lld:pubmed |
| pubmed-article:7594770 | pubmed:meshHeading | pubmed-meshheading:7594770-... | lld:pubmed |
| pubmed-article:7594770 | pubmed:meshHeading | pubmed-meshheading:7594770-... | lld:pubmed |
| pubmed-article:7594770 | pubmed:meshHeading | pubmed-meshheading:7594770-... | lld:pubmed |
| pubmed-article:7594770 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7594770 | pubmed:articleTitle | The influence of somatostatin on glucagon and pancreatic polypeptide secretion in the isolated perfused human pancreas. | lld:pubmed |
| pubmed-article:7594770 | pubmed:affiliation | Department of Surgery, VAMC-West Los Angeles, CA, USA. | lld:pubmed |
| pubmed-article:7594770 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7594770 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7594770 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:7594770 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7594770 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7594770 | lld:pubmed |
