| pubmed-article:7594716 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7594716 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:7594716 | lifeskim:mentions | umls-concept:C0021745 | lld:lifeskim |
| pubmed-article:7594716 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:7594716 | lifeskim:mentions | umls-concept:C0238013 | lld:lifeskim |
| pubmed-article:7594716 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:7594716 | pubmed:dateCreated | 1995-12-28 | lld:pubmed |
| pubmed-article:7594716 | pubmed:abstractText | The immunopathogenesis of invasive aspergillosis and the role played by cytokines are not fully understood. The roles of interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha were investigated in BALB/c mice infected intravenously with 5 x 10(5) Aspergillus fumigatus conidia. Eight groups of animals were studied, including 2 control groups (mice only infected with A. fumigatus and those given cortisone acetate and infected with A. fumigatus) and 6 groups of infected mice either treated or not treated with cortisone acetate and given IFN-gamma, anti-IFN-gamma, TNF-alpha, or anti-TNF-alpha. No deaths occurred among the mice treated with IFN-gamma and TNF-alpha, compared with 40%-80% mortality in the other groups. IFN-gamma- and TNF-alpha-treated mice also had fewer organs from which A. fumigatus could be cultured or demonstrated on histologic examination. These observations suggest that IFN-gamma and TNF-alpha have protective roles in invasive aspergillosis. | lld:pubmed |
| pubmed-article:7594716 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7594716 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7594716 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:7594716 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7594716 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7594716 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7594716 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7594716 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:7594716 | pubmed:issn | 0022-1899 | lld:pubmed |
| pubmed-article:7594716 | pubmed:author | pubmed-author:NagaiHH | lld:pubmed |
| pubmed-article:7594716 | pubmed:author | pubmed-author:ChoiHH | lld:pubmed |
| pubmed-article:7594716 | pubmed:author | pubmed-author:GutMM | lld:pubmed |
| pubmed-article:7594716 | pubmed:author | pubmed-author:KurupVV | lld:pubmed |
| pubmed-article:7594716 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7594716 | pubmed:volume | 172 | lld:pubmed |
| pubmed-article:7594716 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7594716 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7594716 | pubmed:pagination | 1554-60 | lld:pubmed |
| pubmed-article:7594716 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:7594716 | pubmed:meshHeading | pubmed-meshheading:7594716-... | lld:pubmed |
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| pubmed-article:7594716 | pubmed:meshHeading | pubmed-meshheading:7594716-... | lld:pubmed |
| pubmed-article:7594716 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7594716 | pubmed:articleTitle | Interferon-gamma and tumor necrosis factor-alpha protect mice from invasive aspergillosis. | lld:pubmed |
| pubmed-article:7594716 | pubmed:affiliation | Department of Medicine, Medical College of Wisconsin, Milwaukee, USA. | lld:pubmed |
| pubmed-article:7594716 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7594716 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:7594716 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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