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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
1995-12-14
|
| pubmed:abstractText |
NK cells have receptors for MHC class I molecules that inhibit cytotoxicity against target cells. We show that recognition of gamma delta CTL is negatively regulated by receptors for MHC class I molecules. Cytolysis of C1R cells by gamma delta CTL clones was inhibited by the expression of polymorphic HLA class I molecules on target cells and was restored by blocking with anti-HLA class I mAb, suggesting the presence of inhibitory receptors for HLA class I molecules. The receptors for HLA class I molecules on gamma delta T cells were heterogenous. The immune responses to various Ags may be regulated via these inhibitory receptors on T cells and NK cells.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0022-1767
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
155
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
4139-42
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7594567-Clone Cells,
pubmed-meshheading:7594567-Cytotoxicity, Immunologic,
pubmed-meshheading:7594567-HLA-A Antigens,
pubmed-meshheading:7594567-HLA-B Antigens,
pubmed-meshheading:7594567-Humans,
pubmed-meshheading:7594567-Immune Tolerance,
pubmed-meshheading:7594567-Killer Cells, Natural,
pubmed-meshheading:7594567-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:7594567-T-Lymphocytes, Cytotoxic
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Inhibition of gamma delta T cell recognition by receptors for MHC class I molecules.
|
| pubmed:affiliation |
Department of Tumor Biology, University of Tokyo, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|