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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1995-12-28
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pubmed:databankReference |
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pubmed:abstractText |
Chemokines play an important role in immune and inflammatory responses by inducing migration and adhesion of leukocytes. We have isolated a novel chemokine cDNA, designated CCF18, from a cDNA library of an IL-3-dependent murine pro-B cell line, Ba/F3. The cDNA encodes a protein structurally related to the C-C chemokine members. Among this family, C10 shows the highest homology to CCF18, and MIP-1 alpha also has a significant homology but to a lesser extent. CCF18 produced from COS cells induced chemotaxis and Ca2+ flux in CD4+ T cell clones. Moreover, prior administration of MIP-1 alpha desensitized the cells to CCF18. The CCF18 gene (Scya10) was mapped to a middle region of murine chromosome 11, where other genes for several C-C chemokine members are localized. These results clearly indicate that CCF18 is a new member of the C-C chemokine family. Since a high level of CCF18 mRNA is constitutively expressed in macrophage and myeloid cell lines, CCF18 may play a role in inflammatory processes.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
155
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5352-8
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:7594550-Amino Acid Sequence,
pubmed-meshheading:7594550-Animals,
pubmed-meshheading:7594550-Base Sequence,
pubmed-meshheading:7594550-Cells, Cultured,
pubmed-meshheading:7594550-Chemokines,
pubmed-meshheading:7594550-Chemokines, CC,
pubmed-meshheading:7594550-Chemotaxis, Leukocyte,
pubmed-meshheading:7594550-Chromosome Mapping,
pubmed-meshheading:7594550-Cloning, Molecular,
pubmed-meshheading:7594550-Female,
pubmed-meshheading:7594550-Gene Library,
pubmed-meshheading:7594550-Macrophage Inflammatory Proteins,
pubmed-meshheading:7594550-Male,
pubmed-meshheading:7594550-Mice,
pubmed-meshheading:7594550-Mice, Inbred C57BL,
pubmed-meshheading:7594550-Molecular Sequence Data,
pubmed-meshheading:7594550-RNA, Messenger,
pubmed-meshheading:7594550-Transfection
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pubmed:year |
1995
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pubmed:articleTitle |
Molecular cloning and functional characterization of a novel member of the C-C chemokine family.
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pubmed:affiliation |
DNAX Research Institute of Molecular and Cellular Biology, Palo Alto 94304, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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