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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1995-12-28
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pubmed:abstractText |
Extrathymic T cell tolerance to Ags can be achieved through clonal deletion by activation-induced programmed cell death as well as by functional unresponsiveness (anergy) of Ag reactive-T cells. Previous studies demonstrated that in vivo administration of staphylococcal enterotoxin B (SEB) induces SEB-specific T cell anergy. To investigate the molecular mechanisms of T cell anergy, we analyzed the TCR-mediated signal transduction in normal and anergic T cells. Anergic T cells exhibited impaired protein tyrosine phosphorylation on TCR-mediated stimulation. The altered tyrosine phosphorylation in anergic T cells may be caused by a defect in tyrosine phosphorylation of TCR zeta-chain and its subsequent association with ZAP-70 tyrosine kinase. Our data demonstrated that TCR zeta-chain phosphorylation and its sequential interaction with ZAP-70 are essential for the initiation of TCR-mediated signal transduction.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Enterotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Ionophores,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Superantigens,
http://linkedlifedata.com/resource/pubmed/chemical/Tetradecanoylphorbol Acetate,
http://linkedlifedata.com/resource/pubmed/chemical/ZAP-70 Protein-Tyrosine Kinase,
http://linkedlifedata.com/resource/pubmed/chemical/Zap70 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/antigen T cell receptor, zeta chain,
http://linkedlifedata.com/resource/pubmed/chemical/enterotoxin B, staphylococcal
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
155
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5083-7
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:7594516-Animals,
pubmed-meshheading:7594516-Calcium,
pubmed-meshheading:7594516-Clonal Anergy,
pubmed-meshheading:7594516-Enterotoxins,
pubmed-meshheading:7594516-Interleukin-2,
pubmed-meshheading:7594516-Ionophores,
pubmed-meshheading:7594516-Lymphocyte Activation,
pubmed-meshheading:7594516-Membrane Proteins,
pubmed-meshheading:7594516-Mice,
pubmed-meshheading:7594516-Mice, Inbred BALB C,
pubmed-meshheading:7594516-Protein-Tyrosine Kinases,
pubmed-meshheading:7594516-Receptors, Antigen, T-Cell,
pubmed-meshheading:7594516-Signal Transduction,
pubmed-meshheading:7594516-Superantigens,
pubmed-meshheading:7594516-T-Lymphocytes,
pubmed-meshheading:7594516-Tetradecanoylphorbol Acetate,
pubmed-meshheading:7594516-ZAP-70 Protein-Tyrosine Kinase
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pubmed:year |
1995
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pubmed:articleTitle |
Defective TCR-mediated signaling in anergic T cells.
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pubmed:affiliation |
First Department of Internal Medicine, Nagasaki University School of Medicine, Japan.
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pubmed:publicationType |
Journal Article
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