Linked Life Data

7593132

Source:http://linkedlifedata.com/resource/pubmed/id/7593132

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1995-12-12
pubmed:abstractText
The pathogenesis and progression of breast cancer involve complex interactions between hormones and polypeptide growth factors such as insulin-like growth factor-I (IGF-I). IGF-I has been found in stromal fibroblasts derived from malignant and benign breast tissue and it is a mitogen for several breast cancer cell lines. It circulates bound to specific high-affinity binding proteins, which could act as either positive or negative modulators of tumorigenesis. This study has been addressed to characterize IGF-I and its binding proteins in the serum of 85 unselected patients with early breast cancer. The IGF-I concentration was assessed by radioimmunoassay of 69 out of 85 samples before and after dissociation of the IGF-I and IGF-binding protein (IGF-BP) complex whereas IGF-BP of all 85 sera were analyzed by Western ligand blotting; estradiol and progesterone were measured by radioimmunoassay in native serum samples. In our study no differences in IGF-I serum levels between pre- and post-menopausal patients were observed. Patients with higher estradiol and progesterone serum levels did not present different IGF-I concentrations compared to patients with lower serum levels. Furthermore, IGF-I median values were not found to depend on estrogen receptor (ER) status. A heterogeneous quali-quantitative molecular pattern of binding proteins was detected: IGF-BP3 and IGF-BP1 were the most and the least expressed respectively. No correlations between ER status, or parameters related to the hormonal status, and IGF-I or binding proteins expression were observed. No significant differences in IGF-I concentration and IGF-BP expression were observed between cancer patients and a control group matched for age and menopausal status. Finally, preliminary collection of 20 sera derived from patients with late breast cancer was analyzed for IGF-I and its binding proteins content.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0171-5216
pubmed:author
pubmed:issnType
Print
pubmed:volume
121
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
674-82
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:7593132-Adult, pubmed-meshheading:7593132-Aged, pubmed-meshheading:7593132-Aged, 80 and over, pubmed-meshheading:7593132-Breast Neoplasms, pubmed-meshheading:7593132-Case-Control Studies, pubmed-meshheading:7593132-Estradiol, pubmed-meshheading:7593132-Female, pubmed-meshheading:7593132-Humans, pubmed-meshheading:7593132-Insulin-Like Growth Factor Binding Protein 1, pubmed-meshheading:7593132-Insulin-Like Growth Factor Binding Protein 2, pubmed-meshheading:7593132-Insulin-Like Growth Factor Binding Protein 3, pubmed-meshheading:7593132-Insulin-Like Growth Factor Binding Protein 4, pubmed-meshheading:7593132-Insulin-Like Growth Factor Binding Proteins, pubmed-meshheading:7593132-Insulin-Like Growth Factor I, pubmed-meshheading:7593132-Middle Aged, pubmed-meshheading:7593132-Progesterone, pubmed-meshheading:7593132-Radioimmunoassay, pubmed-meshheading:7593132-Radioligand Assay, pubmed-meshheading:7593132-Receptors, Estrogen, pubmed-meshheading:7593132-Statistics, Nonparametric
pubmed:year
1995
pubmed:articleTitle
Insulin-like growth factor-I (IGF-I) and IGF-binding proteins blood serum levels in women with early- and late-stage breast cancer: mutual relationship and possible correlations with patients' hormonal status.
pubmed:affiliation
Istituto Nazionale per la Ricerca sul Cancro, Department of Experimental Pharmacology, Genova, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't