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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
45
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pubmed:dateCreated |
1995-12-26
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pubmed:abstractText |
The Raf-1 serine/threonine kinase transmits proliferative and developmental signals to downstream effectors in the mitogen-activated protein kinase cascade. Studies to date have concentrated on its role in growth factor-mediated activation of the cell cycle. We show here that Raf-1 kinase activity is also highly stimulated during mitosis, with an attendant distinctive electrophoretic mobility shift due to hyperphosphorylation. These results suggest that Raf-1 may play a role in traversal of at least two distinct phases of the cell cycle.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0021-9258
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
270
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
26742-5
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:7592906-3T3 Cells,
pubmed-meshheading:7592906-Animals,
pubmed-meshheading:7592906-Cell Cycle,
pubmed-meshheading:7592906-Enzyme Activation,
pubmed-meshheading:7592906-Mice,
pubmed-meshheading:7592906-Mitosis,
pubmed-meshheading:7592906-Phosphorylation,
pubmed-meshheading:7592906-Platelet-Derived Growth Factor,
pubmed-meshheading:7592906-Protein-Serine-Threonine Kinases,
pubmed-meshheading:7592906-Proto-Oncogene Proteins,
pubmed-meshheading:7592906-Proto-Oncogene Proteins c-raf
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pubmed:year |
1995
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pubmed:articleTitle |
Raf-1 is activated during mitosis.
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pubmed:affiliation |
Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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