Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
22
pubmed:dateCreated
1995-12-19
pubmed:databankReference
pubmed:abstractText
In photosynthetically grown Rhodobacter capsulatus, heme is a qualitatively minor end product of the common tetrapyrrole pathway, but it may play a significant regulatory role. Heme is synthesized from protoporphyrin by the product of the hemH gene, ferrochelatase. We have cloned the R. capsulatus hemH gene by complementation of an Escherichia coli hemH mutant. When a plasmid carrying the hemH gene is returned to R. capsulatus, ferrochelatase activity increases, aminolevulinate synthase activity decreases, and bacteriochlorophyll levels are dramatically lowered. This is the first in vivo evidence to suggest that heme feedback inhibits aminolevulinate synthase in R. capsulatus, thereby reducing porphyrin synthesis.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7592455-13416343, http://linkedlifedata.com/resource/pubmed/commentcorrection/7592455-14041439, http://linkedlifedata.com/resource/pubmed/commentcorrection/7592455-1459957, http://linkedlifedata.com/resource/pubmed/commentcorrection/7592455-1644753, http://linkedlifedata.com/resource/pubmed/commentcorrection/7592455-1835790, http://linkedlifedata.com/resource/pubmed/commentcorrection/7592455-2051480, http://linkedlifedata.com/resource/pubmed/commentcorrection/7592455-2155198, http://linkedlifedata.com/resource/pubmed/commentcorrection/7592455-2987994, http://linkedlifedata.com/resource/pubmed/commentcorrection/7592455-3702737, http://linkedlifedata.com/resource/pubmed/commentcorrection/7592455-6199343, http://linkedlifedata.com/resource/pubmed/commentcorrection/7592455-6302077
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0021-9193
pubmed:author
pubmed:issnType
Print
pubmed:volume
177
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6693-4
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Cloning and overexpression of the Rhodobacter capsulatus hemH gene.
pubmed:affiliation
Department of Microbiology, Louisiana State University, Baton Rouge 70803, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.