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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1995-12-12
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pubmed:abstractText |
GE37468 A is a new thiazolyl peptide antibiotic obtained by fermentation of Streptomyces sp. strain ATCC 55365. It inhibits bacterial protein synthesis by acting on elongation factor Tu and is structurally and functionally related to the GE2270 class of EF-Tu inhibitors. It is active in vitro against Gram-positive bacteria and Bacteroides fragilis, and protects mice against Staphylococcus aureus infection.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0021-8820
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
N
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pubmed:pagination |
780-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7592021-Animals,
pubmed-meshheading:7592021-Anti-Bacterial Agents,
pubmed-meshheading:7592021-Bacillus subtilis,
pubmed-meshheading:7592021-Bacterial Proteins,
pubmed-meshheading:7592021-Bacteroides fragilis,
pubmed-meshheading:7592021-Chromatography, High Pressure Liquid,
pubmed-meshheading:7592021-Female,
pubmed-meshheading:7592021-Gram-Positive Bacteria,
pubmed-meshheading:7592021-Male,
pubmed-meshheading:7592021-Mice,
pubmed-meshheading:7592021-Microbial Sensitivity Tests,
pubmed-meshheading:7592021-Molecular Structure,
pubmed-meshheading:7592021-Peptides, Cyclic,
pubmed-meshheading:7592021-Rats,
pubmed-meshheading:7592021-Staphylococcal Infections,
pubmed-meshheading:7592021-Streptomyces,
pubmed-meshheading:7592021-Thiazoles
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pubmed:year |
1995
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pubmed:articleTitle |
Antibiotic GE37468 A: a new inhibitor of bacterial protein synthesis. I. Isolation and characterization.
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pubmed:affiliation |
Marion Merrell Dow Research Institute, Lepetit Research Center, Gerenzano VA, Italy.
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pubmed:publicationType |
Journal Article,
Comparative Study
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