Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1995-12-15
pubmed:abstractText
This study was undertaken to estimate if dietary iron could stimulate factors which promote spontaneous lung tumorigenesis in A/J mice, by measuring biochemical parameters of oxidative stress on pulmonary nuclei, ornithine decarboxylase (ODC) and spermidine/spermine N1-acetyltransferase (SAT) activities as markers of tumor promotion. Feeding excessive iron (500%) to A/J mice for 28 weeks significantly elevated pulmonary DNA single strand break (DNA-SSB) as well as nuclear thiobarbituric acid reactive substances (TBARS) in connection with the increase of nuclear nonheme iron level. In contrast, nuclear alpha-tocopherol levels in the iron-loaded group significantly decreased as compared to that in the control group. Pulmonary ODC and SAT activities showed increasing tendency on feeding excess iron for 28 weeks. These results suggest that dietary iron stimulates spontaneous lung tumor promotion in A/J mice, partly due to the enhancement of oxidative damage to the pulmonary nuclei.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-9831
pubmed:author
pubmed:issnType
Print
pubmed:volume
65
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
127-31
pubmed:dateRevised
2007-2-21
pubmed:meshHeading
pubmed-meshheading:7591532-Acetyltransferases, pubmed-meshheading:7591532-Administration, Oral, pubmed-meshheading:7591532-Animals, pubmed-meshheading:7591532-Cell Nucleus, pubmed-meshheading:7591532-DNA, Neoplasm, pubmed-meshheading:7591532-Diet, pubmed-meshheading:7591532-Dose-Response Relationship, Drug, pubmed-meshheading:7591532-Incidence, pubmed-meshheading:7591532-Iron, pubmed-meshheading:7591532-Lung, pubmed-meshheading:7591532-Lung Neoplasms, pubmed-meshheading:7591532-Male, pubmed-meshheading:7591532-Mice, pubmed-meshheading:7591532-Mice, Inbred A, pubmed-meshheading:7591532-Ornithine Decarboxylase, pubmed-meshheading:7591532-Oxidative Stress, pubmed-meshheading:7591532-Thiobarbituric Acid Reactive Substances, pubmed-meshheading:7591532-Time Factors, pubmed-meshheading:7591532-Tumor Markers, Biological
pubmed:year
1995
pubmed:articleTitle
Stimulating effect of excess iron feeding on spontaneous lung tumor promotion in mice.
pubmed:affiliation
Division of Applied Food Research, National Institute of Health and Nutrition, Tokyo, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't