Linked Life Data

7590732

Source:http://linkedlifedata.com/resource/pubmed/id/7590732

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1995-12-4
pubmed:abstractText
Cyclophilin A (CyP-A), the major intracellular receptor for the immunosuppressant cyclosporin A (CsA), is a member of the immunophilin class of proteins, which all possess peptidyl-prolyl cis-trans isomerase activity and, therefore, are believed to be involved in protein folding and/or intracellular protein transport. The CyP-A protein is encoded by a single gene; in addition, 15 pseudogenes have been identified. Recently, specific binding of CyP-A to the human immunodeficiency virus type 1 (HIV-1) gag protein has been reported. Interestingly, this interaction can be inhibited by the immunosuppressant CsA and also by nonimmunosuppressive, CyP-A-binding CsA derivatives, which were also shown to exhibit potent anti-HIV-1 activity. Results thus indicate that CyP-A may have an essential function in HIV-1 replication. Using a panel of somatic rodent-human cell hybrids and PCR technology, we localized the coding cyclophilin A gene (PPIA) on chromosome 7 and four pseudogenes (PPIP2, PPIP3, PPIP4, and PPIP6) on chromosomes 14, 10, 18, and 3, respectively. Using chromosome 7 and chromosome 10 deletion hybrid panels, we were able to localize further the coding gene to the region 7p11.2-p13, as confirmed by fluorescence in situ hybridization analysis, and one pseudogene (PPIP3) to the region 10q11.2-q23. This is the first report on the regional mapping of members of the CyP-A gene family.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0888-7543
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
101-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:7590732-Amino Acid Isomerases, pubmed-meshheading:7590732-Animals, pubmed-meshheading:7590732-Base Sequence, pubmed-meshheading:7590732-Carrier Proteins, pubmed-meshheading:7590732-Chromosome Mapping, pubmed-meshheading:7590732-Chromosomes, Human, Pair 10, pubmed-meshheading:7590732-Chromosomes, Human, Pair 14, pubmed-meshheading:7590732-Chromosomes, Human, Pair 18, pubmed-meshheading:7590732-Chromosomes, Human, Pair 3, pubmed-meshheading:7590732-Chromosomes, Human, Pair 7, pubmed-meshheading:7590732-Cyclosporine, pubmed-meshheading:7590732-Humans, pubmed-meshheading:7590732-Hybrid Cells, pubmed-meshheading:7590732-Immunosuppressive Agents, pubmed-meshheading:7590732-Molecular Sequence Data, pubmed-meshheading:7590732-Peptidylprolyl Isomerase, pubmed-meshheading:7590732-Pseudogenes
pubmed:year
1995
pubmed:articleTitle
Cyclophilin A, the major intracellular receptor for the immunosuppressant cyclosporin A, maps to chromosome 7p11.2-p13: four pseudogenes map to chromosomes 3, 10, 14, and 18.
pubmed:affiliation
Sandoz Research Institute, Vienna, Austria.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't