Linked Life Data

7590633

Source:http://linkedlifedata.com/resource/pubmed/id/7590633

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1995-12-12
pubmed:abstractText
We measured urinary growth hormone (U-GH) excretion to estimate the spontaneous growth hormone (GH) production in normal children according to age, sex, height, body mass index, serum insulin-like growth factor-1 (IGF-1), and pubertal status. To assess the clinical usefulness of this parameter, U-GH excretion measurements were obtained in children with GH deficiency (GHD). One hundred and forty-nine prepubertal and 105 pubertal (Tanner stage 2-5) normal children, aged 3-17 years, were studied. They had heights and weights within 2 SD of age-corresponding normal measures. Two consecutive 24-hour urine collections were performed for all of them. Blood sampling for IGF-1 measurement was performed for 54 consented normal subjects. Forty-one children aged 1.8-13.8 years with classical GHD with at least two subnormal GH responses to provocative test were also evaluated. Nocturnal serum GH profile was also performed in 26 of them. GHD children were investigated for U-GH excretion just before human GH therapy. U-GH was measured by a two-step immunoradiometric method that we have developed using two monoclonal antibodies. Despite a wide intra- and interindividual variation, no difference was found related to age or sex in prepubertal normal children. U-GH excretion values were significantly dependent on the pubertal stage with 3.4-fold increased values compared to prepubertal stage in both sexes. In normal children, the U-GH excretion was related to serum IGF-1 values, but no relation was found with the height or the body mass index expressed as standard deviation score.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0301-0163
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
57-63
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
The wide variation in urinary excretion of human growth hormone in normal growing and growth hormone-deficient children limits its clinical usefulness.
pubmed:affiliation
Pediatric Endocrinology and Diabetes Unit, Hôpital Robert-Debré, Paris, France.
pubmed:publicationType
Journal Article, Clinical Trial