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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1995-12-7
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pubmed:abstractText |
This study reports a direct effect of TRH on amylase secretion from isolated rat exocrine pancreatic acinar cells. TRH inhibited carbachol (10(-5) M)-stimulated amylase secretion by a maximum of 24% at a concentration of 10(-11) M (p < 0.05), but did not affect basal amylase release in concentrations from 10(-13) M to 10(-8) M. Ceruletide (3 x 10(-10) M)-stimulated amylase secretion was maximally reduced by 23% at a TRH concentration of 10(-10) M (p < 0.05). Direct stimulation of protein kinase C-mediated secretion by the diacylglycerol analogue 1-oleoyl-2-acetyl-sn-glycerol (OAG) was not altered by TRH. The TRH metabolite cyclo (His-Pro) did not influence basal or stimulated pancreatic secretion in vitro. These findings point to a TRH-mediated modulation of exocrine pancreatic secretion at the receptor site.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1-oleoyl-2-acetylglycerol,
http://linkedlifedata.com/resource/pubmed/chemical/Amylases,
http://linkedlifedata.com/resource/pubmed/chemical/Caerulein,
http://linkedlifedata.com/resource/pubmed/chemical/Carbachol,
http://linkedlifedata.com/resource/pubmed/chemical/Diglycerides,
http://linkedlifedata.com/resource/pubmed/chemical/Gastrointestinal Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Parasympathomimetics,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides, Cyclic,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/Thyrotropin-Releasing Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/histidyl-proline diketopiperazine
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0018-5043
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
367-71
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pubmed:dateRevised |
2009-2-19
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pubmed:meshHeading |
pubmed-meshheading:7590625-Amylases,
pubmed-meshheading:7590625-Animals,
pubmed-meshheading:7590625-Caerulein,
pubmed-meshheading:7590625-Carbachol,
pubmed-meshheading:7590625-Cell Separation,
pubmed-meshheading:7590625-Diglycerides,
pubmed-meshheading:7590625-Gastrointestinal Agents,
pubmed-meshheading:7590625-Kinetics,
pubmed-meshheading:7590625-Male,
pubmed-meshheading:7590625-Pancreas,
pubmed-meshheading:7590625-Parasympathomimetics,
pubmed-meshheading:7590625-Peptides, Cyclic,
pubmed-meshheading:7590625-Piperazines,
pubmed-meshheading:7590625-Protein Kinase C,
pubmed-meshheading:7590625-Rats,
pubmed-meshheading:7590625-Rats, Wistar,
pubmed-meshheading:7590625-Thyrotropin-Releasing Hormone
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pubmed:year |
1995
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pubmed:articleTitle |
Inhibitory effect of thyrotropin-releasing hormone on enzyme secretion from isolated rat pancreatic acinar cells.
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pubmed:affiliation |
Rehabilitationsklinik Neresheim, Germany.
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pubmed:publicationType |
Journal Article
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