| pubmed-article:7590243 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7590243 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:7590243 | lifeskim:mentions | umls-concept:C0441471 | lld:lifeskim |
| pubmed-article:7590243 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:7590243 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:7590243 | lifeskim:mentions | umls-concept:C1622990 | lld:lifeskim |
| pubmed-article:7590243 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:7590243 | lifeskim:mentions | umls-concept:C0243958 | lld:lifeskim |
| pubmed-article:7590243 | pubmed:issue | 21 | lld:pubmed |
| pubmed-article:7590243 | pubmed:dateCreated | 1995-12-26 | lld:pubmed |
| pubmed-article:7590243 | pubmed:abstractText | The proteins and RNA regulatory elements that control tissue-specific pre-mRNA splicing in mammalian cells are mostly unknown. In this study, a set of proteins is identified that binds to a splicing regulatory element downstream of the neuron specific c-src N1 exon. This complex of proteins bound specifically to a short RNA containing the regulatory sequence in neuronal extracts that splice the N1 exon. It was not seen in non-neuronal cell extracts that fail to splice this exon. UV-cross-linking experiments identified a neuron-specific 75-kD protein and several nontissue-specific proteins, including the 53-kD heterogeneous nuclear ribonucleoprotein F (hnRNP F), as components of this complex. Although present in both extracts, hnRNP F binds tightly to the RNA only in the neuronal extracts. A mutation in the regulatory RNA sequence, that inhibits N1 splicing in vivo, abolished formation of the neuron-specific complex and the binding of the neuron-specific 75-kD protein. Competition experiments in the two extracts show that the binding of the neuronal protein complex to the src pre-mRNA is required to activate N1 exon splicing in vitro. Antibody inhibition experiments indicate that the hnRNP F protein is a functional part of this complex. The assembly of regulatory complexes from both constitutive and specific proteins is likely to be a general feature of tissue-specific splicing regulation. | lld:pubmed |
| pubmed-article:7590243 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7590243 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7590243 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7590243 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7590243 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7590243 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7590243 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7590243 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7590243 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7590243 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7590243 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7590243 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7590243 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7590243 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:7590243 | pubmed:issn | 0890-9369 | lld:pubmed |
| pubmed-article:7590243 | pubmed:author | pubmed-author:MisMM | lld:pubmed |
| pubmed-article:7590243 | pubmed:author | pubmed-author:BlackD LDL | lld:pubmed |
| pubmed-article:7590243 | pubmed:author | pubmed-author:ChaoR BRB | lld:pubmed |
| pubmed-article:7590243 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7590243 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:7590243 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:7590243 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7590243 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7590243 | pubmed:pagination | 2659-71 | lld:pubmed |
| pubmed-article:7590243 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:7590243 | pubmed:meshHeading | pubmed-meshheading:7590243-... | lld:pubmed |
| pubmed-article:7590243 | pubmed:meshHeading | pubmed-meshheading:7590243-... | lld:pubmed |
| pubmed-article:7590243 | pubmed:meshHeading | pubmed-meshheading:7590243-... | lld:pubmed |
| pubmed-article:7590243 | pubmed:meshHeading | pubmed-meshheading:7590243-... | lld:pubmed |
| pubmed-article:7590243 | pubmed:meshHeading | pubmed-meshheading:7590243-... | lld:pubmed |
| pubmed-article:7590243 | pubmed:meshHeading | pubmed-meshheading:7590243-... | lld:pubmed |
| pubmed-article:7590243 | pubmed:meshHeading | pubmed-meshheading:7590243-... | lld:pubmed |
| pubmed-article:7590243 | pubmed:meshHeading | pubmed-meshheading:7590243-... | lld:pubmed |
| pubmed-article:7590243 | pubmed:meshHeading | pubmed-meshheading:7590243-... | lld:pubmed |
| pubmed-article:7590243 | pubmed:meshHeading | pubmed-meshheading:7590243-... | lld:pubmed |
| pubmed-article:7590243 | pubmed:meshHeading | pubmed-meshheading:7590243-... | lld:pubmed |
| pubmed-article:7590243 | pubmed:meshHeading | pubmed-meshheading:7590243-... | lld:pubmed |
| pubmed-article:7590243 | pubmed:meshHeading | pubmed-meshheading:7590243-... | lld:pubmed |
| pubmed-article:7590243 | pubmed:meshHeading | pubmed-meshheading:7590243-... | lld:pubmed |
| pubmed-article:7590243 | pubmed:meshHeading | pubmed-meshheading:7590243-... | lld:pubmed |
| pubmed-article:7590243 | pubmed:meshHeading | pubmed-meshheading:7590243-... | lld:pubmed |
| pubmed-article:7590243 | pubmed:meshHeading | pubmed-meshheading:7590243-... | lld:pubmed |
| pubmed-article:7590243 | pubmed:meshHeading | pubmed-meshheading:7590243-... | lld:pubmed |
| pubmed-article:7590243 | pubmed:meshHeading | pubmed-meshheading:7590243-... | lld:pubmed |
| pubmed-article:7590243 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7590243 | pubmed:articleTitle | The generally expressed hnRNP F is involved in a neural-specific pre-mRNA splicing event. | lld:pubmed |
| pubmed-article:7590243 | pubmed:affiliation | Molecular Biology Institute, University of California at Los Angeles 90024-1662, USA. | lld:pubmed |
| pubmed-article:7590243 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7590243 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7590243 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7590243 | lld:pubmed |
