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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
12
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pubmed:dateCreated |
1995-12-28
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pubmed:abstractText |
Two- and three-color cytofluorimetric techniques were used to study the expression patterns of the activation antigen HLA-DR on peripheral blood immunoregulatory T-cells from 25 patients with newly diagnosed insulin-dependent diabetes mellitus (IDDM) and 14 age- and sex-matched control subjects. The mean percentage of total activated (CD3+HLA-DR+) T-cells was significantly elevated in the IDDM group compared with the control group (P < 0.001). In control subjects, basal activation of CD4+ and CD8+ lymphocytes accounted for the low percentage levels of activated T-cells. In contrast, the majority of IDDM patients showed an unbalanced activation of CD4+ and CD8+ lymphocytes with predominant activation of the CD8+ lymphocyte subset. The composition of the activated T-cell fraction was dependent on the composition of the total (activated + nonactivated) T-cell population, as indicated by the positive correlation between the CD4+/CD8+ T-cell ratios in these two cell populations (r = 0.714; P < 0.001). Excessive activation of CD8+ T-cells was attributable to similar increases in the proportions of CD8+ CD45RA+HLA-DR+ (naive) and CD8+CD45RA-HLA-DR+ (memory) cells. Analysis of the CD11b-defined subsets revealed predominant activation of CD8+ CD11b- (cytotoxic) T-cells; CD8+ CD16+ HLA-DR+ natural killer cells were unchanged. The distribution of HLA-DR+ cells among subsets of CD4+ T-cells differed from the pattern in the CD8+ population in that selective activation of CD4+ CD45RA- (memory, helper-inducer) cells accounted for the small increase in activated CD4+ cells.(ABSTRACT TRUNCATED AT 250 WORDS)
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0012-1797
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1414-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7589848-Adolescent,
pubmed-meshheading:7589848-Adult,
pubmed-meshheading:7589848-Antigens, CD3,
pubmed-meshheading:7589848-Autoantibodies,
pubmed-meshheading:7589848-CD4-Positive T-Lymphocytes,
pubmed-meshheading:7589848-CD8-Positive T-Lymphocytes,
pubmed-meshheading:7589848-Child,
pubmed-meshheading:7589848-Diabetes Mellitus, Type 1,
pubmed-meshheading:7589848-Female,
pubmed-meshheading:7589848-Flow Cytometry,
pubmed-meshheading:7589848-HLA-DR Antigens,
pubmed-meshheading:7589848-Humans,
pubmed-meshheading:7589848-Islets of Langerhans,
pubmed-meshheading:7589848-Killer Cells, Natural,
pubmed-meshheading:7589848-Lymphocyte Activation,
pubmed-meshheading:7589848-Male
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pubmed:year |
1995
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pubmed:articleTitle |
Aberrant activation of CD8+ T-cell and CD8+ T-cell subsets in patients with newly diagnosed IDDM.
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pubmed:affiliation |
Department of Experimental and Clinical Endocrinology, University of Greifswald, Karlsburg, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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