rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1995-12-28
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pubmed:abstractText |
The expression of CYP1B1 has been identified in breast cancer using the reverse transcriptase-polymerase chain reaction and immunoblotting. CYP1B1 mRNA was expressed in the majority of breast tumours and immunoblotting of breast tumours identified a single protein band of molecular weight 60 kDa corresponding to the predicted molecular weight of human CYP1B1. This is the first study to identify CYP1B1 expression in a tumour where it may represent a previously unknown pathway for the metabolism of oestradiol and chemotherapeutic drugs.
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pubmed:grant |
|
pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
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pubmed:month |
Oct
|
pubmed:issn |
0014-5793
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pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
30
|
pubmed:volume |
374
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
270-2
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7589551-Adult,
pubmed-meshheading:7589551-Aged,
pubmed-meshheading:7589551-Aged, 80 and over,
pubmed-meshheading:7589551-Aryl Hydrocarbon Hydroxylases,
pubmed-meshheading:7589551-Base Sequence,
pubmed-meshheading:7589551-Breast Neoplasms,
pubmed-meshheading:7589551-Cytochrome P-450 Enzyme System,
pubmed-meshheading:7589551-DNA Primers,
pubmed-meshheading:7589551-Female,
pubmed-meshheading:7589551-Humans,
pubmed-meshheading:7589551-Immunoblotting,
pubmed-meshheading:7589551-Middle Aged,
pubmed-meshheading:7589551-Molecular Sequence Data,
pubmed-meshheading:7589551-Polymerase Chain Reaction,
pubmed-meshheading:7589551-RNA, Messenger,
pubmed-meshheading:7589551-Transcription, Genetic
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pubmed:year |
1995
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pubmed:articleTitle |
Expression of cytochrome P450 CYP1B1 in breast cancer.
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pubmed:affiliation |
Department of Pathology, University of Aberdeen, UK.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|