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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1995-11-24
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pubmed:databankReference |
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pubmed:abstractText |
The DNA sequence encoding human placental thioredoxin reductase has been determined. Of the 3826 base pairs sequenced, 1650 base pairs were in an open reading frame encoding a mature protein with 495 amino acids and a calculated molecular mass of 54,171. Sequence analysis showed strong similarity to glutathione reductases and other NADPH-dependent reductases. Human thioredoxin reductase contains the redox-active cysteines in the putative FAD binding domain and has a dimer interface domain not previously seen with prokaryote and lower eukaryote thioredoxin reductases.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
373
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5-9
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:7589432-Amino Acid Sequence,
pubmed-meshheading:7589432-Animals,
pubmed-meshheading:7589432-Bacteria,
pubmed-meshheading:7589432-Base Composition,
pubmed-meshheading:7589432-Base Sequence,
pubmed-meshheading:7589432-Cloning, Molecular,
pubmed-meshheading:7589432-Escherichia coli,
pubmed-meshheading:7589432-Female,
pubmed-meshheading:7589432-Glutathione Reductase,
pubmed-meshheading:7589432-Humans,
pubmed-meshheading:7589432-Mice,
pubmed-meshheading:7589432-Molecular Sequence Data,
pubmed-meshheading:7589432-Molecular Weight,
pubmed-meshheading:7589432-Oligodeoxyribonucleotides,
pubmed-meshheading:7589432-Open Reading Frames,
pubmed-meshheading:7589432-Placenta,
pubmed-meshheading:7589432-Plants,
pubmed-meshheading:7589432-Pregnancy,
pubmed-meshheading:7589432-Sequence Homology, Amino Acid,
pubmed-meshheading:7589432-Thioredoxin-Disulfide Reductase
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pubmed:year |
1995
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pubmed:articleTitle |
Cloning and sequencing of a human thioredoxin reductase.
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pubmed:affiliation |
Arizona Cancer Center, Tucson 85724, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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