|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
1995-11-29
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|
pubmed:abstractText |
Patients with rheumatoid arthritis have a reduced prevalence of immunoglobulin G (IgG) oligosaccharide chains terminating in galactose, thus exposing N-acetylglucosamine. We analyzed IgG glycosylation in patients with rheumatoid arthritis, patients with early synovitis, and in controls by means of isoelectric focusing and lectin-affinoblotting. The ratio of N-terminal N-acetylglucosamine and galactose was determined using specific biotin-labeled lectins. The IgG glycosylation state may well be of clinical value in the differential diagnosis of patients presenting with early synovitis.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0173-0835
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
16
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
811-2
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:7588567-Arthritis, Rheumatoid,
pubmed-meshheading:7588567-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:7588567-Glycosylation,
pubmed-meshheading:7588567-Humans,
pubmed-meshheading:7588567-Immunoblotting,
pubmed-meshheading:7588567-Immunoglobulin G,
pubmed-meshheading:7588567-Isoelectric Focusing,
pubmed-meshheading:7588567-Lectins,
pubmed-meshheading:7588567-Plant Lectins,
pubmed-meshheading:7588567-Ricin,
pubmed-meshheading:7588567-Synovitis
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|
pubmed:year |
1995
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|
pubmed:articleTitle |
Detection of immunoglobulin G glycosylation changes in patients with rheumatoid arthritis by means of isoelectric focusing and lectin-affinoblotting.
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|
pubmed:affiliation |
Department of Rheumatology, Leipzig University, Germany.
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|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
