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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1979-2-23
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pubmed:abstractText |
After atropine administration the anesthetized dog exhibits significant spontaneous pyloric contractile activity and an inhibition-relaxation response upon electrical vagal stimulation. This inhibition-relaxation response was completely blocked by tetrodotoxin administration and by transection of the intraabdominal vagal nerves. In addition, tetrodotoxin administration caused a dramatic increase in spontaneous pyloric motor activity. The histaminergic receptor antagonists diphenhydramine and cimetidine did not block the inhibition-relaxation response. The octapeptide of cholecystokinin (CCK-OP) caused a dose-dependent increase in antral and pyloric motor activity which was significantly decreased by atropine administration. Therefore, histamine and CCK do not appear to play a significant role in the vagally mediated inhibition-relaxation response of the canine pylorus or in the atropine-resistant spontaneous pyloric motor activity.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0002-9610
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
137
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
92-8
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:758846-Animals,
pubmed-meshheading:758846-Atropine,
pubmed-meshheading:758846-Autonomic Nerve Block,
pubmed-meshheading:758846-Cholecystokinin,
pubmed-meshheading:758846-Dogs,
pubmed-meshheading:758846-Duodenum,
pubmed-meshheading:758846-Electric Stimulation,
pubmed-meshheading:758846-Gastrointestinal Motility,
pubmed-meshheading:758846-Histamine,
pubmed-meshheading:758846-Muscle, Smooth,
pubmed-meshheading:758846-Muscle Contraction,
pubmed-meshheading:758846-Pyloric Antrum,
pubmed-meshheading:758846-Pylorus,
pubmed-meshheading:758846-Tetrodotoxin,
pubmed-meshheading:758846-Vagotomy,
pubmed-meshheading:758846-Vagus Nerve
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pubmed:year |
1979
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pubmed:articleTitle |
Neural control of the canine pylorus.
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pubmed:publicationType |
Journal Article
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