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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1995-11-27
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pubmed:abstractText |
Insulin-like growth factor I (IGF I) plays a key role in the regulation of cell proliferation. Progression of the cell cycle is regulated by stimulatory and inhibitory pathways. In order to understand the mechanisms through which IGF I regulates cardiac muscle growth, we have studied the effects of IGF I on inhibitory pathways involving p53 and WAF1 in cultured cardiac muscle cell line H9C2. The onset of DNA synthesis in response to IGF I stimulation was preceded by activation of p53 expression. In addition, IGF I increased p53-dependent and p53-independent induction of WAF1 in H9C2 cells. Dose-response studies showed that IGF I effects on p53-dependent and p53-independent induction of WAF1 occur at physiological concentrations of IGF I. These data indicate that IGF I coordinately regulates inhibitory pathways of cell cycle progression, and that p53-dependent and p53-independent induction of WAF1 may provide negative control mechanisms to regulate stimulatory pathways of cell cycle progression activated by IGF I.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cdkn1a protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor I,
http://linkedlifedata.com/resource/pubmed/chemical/Luciferases,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0013-7227
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
136
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5240-3
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:7588265-Animals,
pubmed-meshheading:7588265-Binding Sites,
pubmed-meshheading:7588265-Cell Cycle,
pubmed-meshheading:7588265-Cell Division,
pubmed-meshheading:7588265-Cell Line,
pubmed-meshheading:7588265-Cyclin-Dependent Kinase Inhibitor p21,
pubmed-meshheading:7588265-Cyclins,
pubmed-meshheading:7588265-DNA,
pubmed-meshheading:7588265-Embryo, Mammalian,
pubmed-meshheading:7588265-Gene Expression,
pubmed-meshheading:7588265-Insulin-Like Growth Factor I,
pubmed-meshheading:7588265-Luciferases,
pubmed-meshheading:7588265-Myocardium,
pubmed-meshheading:7588265-Polymerase Chain Reaction,
pubmed-meshheading:7588265-Promoter Regions, Genetic,
pubmed-meshheading:7588265-RNA, Messenger,
pubmed-meshheading:7588265-Rats,
pubmed-meshheading:7588265-Recombinant Fusion Proteins,
pubmed-meshheading:7588265-Transfection,
pubmed-meshheading:7588265-Tumor Suppressor Protein p53
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pubmed:year |
1995
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pubmed:articleTitle |
Coordinated effects of insulin-like growth factor I on inhibitory pathways of cell cycle progression in cultured cardiac muscle cells.
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pubmed:affiliation |
Department of Medicine, University of California, Irvine, 92717, USA.
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pubmed:publicationType |
Journal Article
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