Linked Life Data

7587600

Source:http://linkedlifedata.com/resource/pubmed/id/7587600

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1995-12-5
pubmed:abstractText
The point mutation in the precore region of hepatitis B viral genome (nt83) was tested with the method of mispairing PCR-RFLP in 54 chronic hepatitis B patients all confirmed by liver biopsy. The over all detection rate of pre-C mutation was 66.7% and the detection rate of pre-C mutation in chronic active hepatitis patients was as high as 80.0%, being significantly higher than that in chronic persistent hepatitis (46.7%). The detection rate of pre-C mutation was 41.2% in hepatitis B e antigen (HBeAg) positive group and 63.3% in anti-HBe(+) group respectively. The detection rate in anti-HBe(+) patients with normal alanine transaminase activity was as high as 82.4%. During the period of follow up it was found that pre-C mutation may appear and disappear or may persist continually. The results suggested that pre-C mutation was extremely common in chronic hepatitis B virus (HBV) infection. The coexistence of the mutant type and wild type in the patients may be considered as the natural course of HBV chronic infection. Further study on the cause and effect relation between pre-C mutation and genesis of chronic active hepatitis and liver cirrhosis is urgently needed.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0578-1426
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
232-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
[A kinetic study of hepatitis B virus pre-C gene mutation].
pubmed:affiliation
260th Hospital, PLA, Shijiazhuang.
pubmed:publicationType
Journal Article, English Abstract