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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1995-12-7
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pubmed:abstractText |
Optically active isomers of 6-fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H- [1,3] thiazeto [3,2-alpha] quinoline-3- carboxylic acid (NM394, 3) were prepared through optical resolution of their racemic intermediate ( +/- )-1 by high-performance liquid chromatography (HPLC). The absolute configuration at the C-1 position in the thiazeto-quinolone ring of ( - )-3 was confirmed by X-ray analysis ( - )-4 to be S. The in vitro antibacterial activity of ( - )-3 was 2--8 times that of (+)-3.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0009-2363
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
43
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1238-40
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pubmed:dateRevised |
2008-7-23
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pubmed:meshHeading |
pubmed-meshheading:7586065-Anti-Infective Agents,
pubmed-meshheading:7586065-Bacillus subtilis,
pubmed-meshheading:7586065-Crystallography, X-Ray,
pubmed-meshheading:7586065-Escherichia coli,
pubmed-meshheading:7586065-Fluoroquinolones,
pubmed-meshheading:7586065-Microbial Sensitivity Tests,
pubmed-meshheading:7586065-Piperazines,
pubmed-meshheading:7586065-Pseudomonas aeruginosa,
pubmed-meshheading:7586065-Quinolones,
pubmed-meshheading:7586065-Staphylococcus aureus,
pubmed-meshheading:7586065-Stereoisomerism,
pubmed-meshheading:7586065-Structure-Activity Relationship
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pubmed:year |
1995
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pubmed:articleTitle |
Studies on pyridonecarboxylic acids. IV. Synthesis and antibacterial activity evaluation of S-(-)- and R-(+)-6-fluoro-1-methyl-4-oxo-7- (1-piperazinyl)-4H-[1,3] thiazeto[3,2-a]quinoline-3-carboxylic acids.
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pubmed:affiliation |
Chemistry Laboratory, Nippon Shinyaku Company, Ltd., Kyoto, Japan.
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pubmed:publicationType |
Journal Article
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