Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
21
pubmed:dateCreated
1995-12-6
pubmed:abstractText
We have shown previously that Listeria monocytogenes, a gram-positive, facultative intracellular bacterium, is a potent vector for targeting tumor-specific antigens to the immune system. After parenteral administration, we observed protection against both renal and colorectal mouse tumors and regression of established renal tumors. In the present study, we have exploited the fact that the normal route of infection of this organism is through the gut. We show that an L. monocytogenes recombinant that expresses a model tumor antigen is an effective cancer immunotherapeutic agent when delivered orally in that it causes regression of established, macroscopic mouse renal and colorectal tumors expressing the same antigen.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0008-5472
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
55
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4776-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:7585503-Administration, Oral, pubmed-meshheading:7585503-Animals, pubmed-meshheading:7585503-Antigens, Neoplasm, pubmed-meshheading:7585503-Antigens, Viral, pubmed-meshheading:7585503-Bacterial Vaccines, pubmed-meshheading:7585503-Carcinoma, Renal Cell, pubmed-meshheading:7585503-Colonic Neoplasms, pubmed-meshheading:7585503-Gene Products, gag, pubmed-meshheading:7585503-Immunotherapy, Active, pubmed-meshheading:7585503-Kidney Neoplasms, pubmed-meshheading:7585503-Listeria monocytogenes, pubmed-meshheading:7585503-Melanoma, Experimental, pubmed-meshheading:7585503-Mice, pubmed-meshheading:7585503-Mice, Inbred BALB C, pubmed-meshheading:7585503-Mice, Inbred C57BL, pubmed-meshheading:7585503-Neoplasms, Experimental, pubmed-meshheading:7585503-Nucleoproteins, pubmed-meshheading:7585503-RNA-Binding Proteins, pubmed-meshheading:7585503-Recombinant Proteins, pubmed-meshheading:7585503-T-Lymphocytes, Cytotoxic, pubmed-meshheading:7585503-Transduction, Genetic, pubmed-meshheading:7585503-Tumor Cells, Cultured, pubmed-meshheading:7585503-Vaccines, Synthetic, pubmed-meshheading:7585503-Viral Core Proteins
pubmed:year
1995
pubmed:articleTitle
Regression of established tumors in mice mediated by the oral administration of a recombinant Listeria monocytogenes vaccine.
pubmed:affiliation
Department of Microbiology, University of Pennsylvania, Philadelphia 19104-6076, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't