|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
1995-12-26
|
|
pubmed:abstractText |
Expression of the RI alpha subunit of cAMP-dependent protein kinase type I is enhanced in human cancer cell lines, in primary tumours, in cells after transformation and in cells upon stimulation of growth. We have investigated the effect of sequence-specific inhibition of RI alpha gene expression on in vivo tumour growth. We report that single injection RI alpha antisense treatment results in a reduction in RI alpha expression and inhibition of tumour growth. Tumour cells behaved like untransformed cells by making less protein kinase type I. The RI alpha antisense, which produces a biochemical imprint for growth control, requires infrequent dosing to halt neoplastic growth in vivo.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
1078-8956
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
1
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
528-33
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:7585118-Animals,
pubmed-meshheading:7585118-Base Sequence,
pubmed-meshheading:7585118-Carcinoma,
pubmed-meshheading:7585118-Cell Transformation, Viral,
pubmed-meshheading:7585118-Colonic Neoplasms,
pubmed-meshheading:7585118-Cyclic AMP-Dependent Protein Kinases,
pubmed-meshheading:7585118-Drug Screening Assays, Antitumor,
pubmed-meshheading:7585118-Gene Therapy,
pubmed-meshheading:7585118-Humans,
pubmed-meshheading:7585118-Injections, Subcutaneous,
pubmed-meshheading:7585118-Isoenzymes,
pubmed-meshheading:7585118-Mice,
pubmed-meshheading:7585118-Mice, Nude,
pubmed-meshheading:7585118-Molecular Sequence Data,
pubmed-meshheading:7585118-Neoplasm Proteins,
pubmed-meshheading:7585118-Neoplasm Transplantation,
pubmed-meshheading:7585118-Oligonucleotides, Antisense
|
|
pubmed:year |
1995
|
|
pubmed:articleTitle |
A single-injection protein kinase A-directed antisense treatment to inhibit tumour growth.
|
|
pubmed:affiliation |
Cellular Biochemistry Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1750, USA.
|
|
pubmed:publicationType |
Journal Article
|
